Clinical Correlations of Brain Lesion Location in Multiple Sclerosis: Voxel-Based Analysis of a Large Clinical Trial Dataset

Brain Topography
Anna AltermattTill Sprenger

Abstract

There is a limited correlation between white matter (WM) lesion load as determined by magnetic resonance imaging and disability in multiple sclerosis (MS). The reasons for this so-called clinico-radiological paradox are diverse and may, at least partly, relate to the fact that not just the overall lesion burden, but also the exact anatomical location of lesions predict the severity and type of disability. We aimed at studying the relationship between lesion distribution and disability using a voxel-based lesion probability mapping approach in a very large dataset of MS patients. T2-weighted lesion masks of 2348 relapsing-remitting MS patients were spatially normalized to standard stereotaxic space by non-linear registration. Relations between supratentorial WM lesion locations and disability measures were assessed using a non-parametric ANCOVA (Expanded Disability Status Scale [EDSS]; Multiple Sclerosis Functional Composite, and subscores; Modified Fatigue Impact Scale) or multinomial ordinal logistic regression (EDSS functional subscores). Data from 1907 (81%) patients were included in the analysis because of successful registration. The lesion mapping showed similar areas to be associated with the different disability scales:...Continue Reading

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Citations

Jul 27, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Stephen C Krieger, Fred D Lublin
Jan 27, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Zina-Mary ManjalyKlaas Enno Stephan
Sep 20, 2019·Scientific Reports·Koji KamagataShigeki Aoki
Jul 17, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Laura CacciaguerraMassimo Filippi
Mar 5, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Laura GaetanoTill Sprenger
Apr 6, 2019·Current Opinion in Neurology·Chenyu Tim WangYael Barnett
Oct 28, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Andreas JohnenSven G Meuth
Jul 14, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lorenzo ContiMassimo Filippi
Nov 21, 2021·Acta Neurologica Scandinavica·Asta TheodorsdottirMads Henrik Ravnborg
Jul 12, 2020·Diagnostic and Interventional Imaging·P RocaUNKNOWN Imaging group

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Software Mentioned

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