Abstract
In a prospective study of 93 consecutive untreated patients with B-cell chronic lymphocytic leukemia, we examined the clinical relevance of surface immunoglobulin (sIg) heavy chain (HC) and light chain (LC) isotypes, CD11c or CD25 expression, and the presence of trisomy 12 by fluorescence in situ hybridization (FISH). Careful morphologic evaluation was performed to exclude patients with other forms of chronic lymphoid leukemias, including mantle cell lymphoma, prolymphocytic leukemia, and leukemia phase of lymphoma. In addition, clonally restricted sIg and CD5 surface determinant were expressed in all patients. Clinical presentation, including blood cell counts, clinical stage, and organomegaly, did not correlate with any of the measured variables. After a median follow-up period of 3 years, the particular HC or LC isotype or CD11c expression did not correlate with either disease progression or treatment-free survival. However, trisomy 12 and CD25 expressions were both associated with accelerated disease progression and a shorter treatment-free survival time. Our results confirm the adverse prognostic significance of trisomy 12 expression in chronic lymphocytic leukemia and suggest that CD25 expression may have an unfavorable c...Continue Reading
References
May 4, 1992·Annals of the New York Academy of Sciences·T PaglieroniM R MacKenzie
Apr 1, 1992·Mayo Clinic Proceedings·A Tefferi, R L Phyliky
Jun 1, 1992·Leukemia Research·E MontserratC Rozman
Sep 13, 1990·The New England Journal of Medicine·G JuliussonG Gahrton
Nov 1, 1990·British Journal of Haematology·D G OscierM Fitchett
Aug 1, 1988·Mayo Clinic Proceedings·A TefferiR L Phyliky
Jun 1, 1989·Journal of Clinical Pathology·J M BennettC Sultan
Mar 1, 1988·British Journal of Haematology·R Dadmarz, J C Cawley
Jul 15, 1988·Cancer Genetics and Cytogenetics·P C NowellE C Besa
Aug 1, 1988·Cancer·G JuliussonG Gahrton
May 1, 1988·Blut·L W TerstappenJ Greve
May 1, 1987·British Journal of Haematology·T J HamblinJ L Smith
Sep 15, 1980·Cancer·M D LipshutzA Sawitsky
Mar 1, 1994·Leukemia & Lymphoma·T Lavabre-BertrandM Navarro
Sep 1, 1994·The American Journal of the Medical Sciences·P B CaguioaR P McCaffrey
Aug 1, 1994·Leukemia & Lymphoma·T E WitzigR B Jenkins
Mar 1, 1994·Leukemia & Lymphoma·A Waage, T Espevik
Citations
May 25, 2012·Annals of Hematology·Lev ShvidelUNKNOWN Israeli CLL Study Group
Apr 24, 1999·Cancer Genetics and Cytogenetics·W J HoganT E Witzig
Aug 9, 2001·Reviews in Clinical and Experimental Hematology·F Caligaris-Cappio
Jan 6, 2006·American Journal of Clinical Pathology·Howard J MeyersonDavid Kaplan
Nov 17, 2001·American Journal of Clinical Pathology·J L FraterE D Hsi
Jun 19, 2002·European Journal of Haematology·Viktoria HjalmarEva Kimby
Apr 17, 2010·American Journal of Clinical Pathology·Nagwa M HassaneinAnand S Lagoo
Feb 21, 2006·British Journal of Haematology·K S Reddy
Jun 22, 2010·Internal Medicine Journal·M L SuldaP J Macardle
Oct 26, 2011·Leukemia & Lymphoma·Pauline Y HuangRichard I Christopherson
Sep 17, 2004·Leukemia & Lymphoma·Patricia AounWarren G Sanger
Feb 16, 2000·Leukemia & Lymphoma·G D'ArenaM Carotenuto
Nov 2, 2016·Current Protocols in Toxicology·Katy Phelan, Kristin M May
Jun 2, 2016·Current Protocols in Pharmacology·Katy Phelan, Kristin M May
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Caligaris-Cappio, T J Hamblin
Jul 10, 1999·Current Opinion in Hematology·W G Wierda, T J Kipps