Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus

The Journal of Infectious Diseases
Wenda GuanChris K P Mok

Abstract

Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.

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Citations

Apr 26, 2019·Intensive Care Medicine·Benjamin M TangAnthony S McLean
Jan 9, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marios KoutsakosKanta Subbarao
Jan 8, 2021·Frontiers in Veterinary Science·Wenxiao GongMeilin Jin
Apr 8, 2021·Nature Reviews. Microbiology·Tim FlerlageStacey Schultz-Cherry

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