PMID: 9527118Apr 4, 1998Paper

Clinical correlations with allelotype in supraglottic squamous cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
S B ScholnickM R Zequeira

Abstract

Frequent allelic loss at a genetically polymorphic locus in tumors is an established marker for the presence of a tumor suppressor gene in the neighboring chromosomal region. This technique can be used to identify novel tumor suppressor genes and to monitor their status before the cloning of the gene itself. We have used the polymerase chain reaction and microsatellite loci on all 39 nonacrocentric autosomal chromosomal arms to identify sites of frequent allelic loss in squamous cell carcinomas of the supraglottic larynx. Our allelotype identified seven chromosomal arms (3p, 5q, 8p, 9p, 9q, 13q, and 17p) likely to contain tumor suppressor genes frequently inactivated during squamous tumorigenesis in the larynx. We tested for associations between allelic losses on these chromosomal arms and the clinical and histopathologic features of these tumors. There were no correlations with either T or N classifications. Allelic loss on chromosomal arm 13q is significantly associated with a number of histopathologic features characteristic of poorly differentiated or histologically aggressive tumors. Allelic loss on this arm also exhibits statistical trends toward association with early tumor recurrence and poor survival. The association w...Continue Reading

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Citations

Sep 30, 1999·International Journal of Cancer. Journal International Du Cancer·V K GuptaS B Scholnick
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·C L RosenbergT L Delaney
Jan 22, 2002·The Laryngoscope·M RaskeD B Welling
Sep 23, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·S George Lesinski
Aug 19, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kamal-Eldin Ahmed Abou-Elhamd, Tito Naeem Habib
Jun 18, 2004·Journal of Korean Medical Science·Woo Jeong YooChang Suk Kang

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