Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils

Expert Opinion on Drug Delivery
Shymaa HatemSeham A Elkheshen

Abstract

The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA). NLCs were characterized for their size, charge, drug entrapment, anti-oxidant potential, physical stability, in vitro release, surface morphology, and ex-vivo skin deposition. Their merits were clinically tested on patients suffering from AGA by calculating the degree of improvement, conduction of hair pull test, histometric assessment, and dermoscopic evaluation. Results revealed that melatonin NLCs showed nanometer size, negatively charged surface, high entrapment efficiency, and high anti-oxidant potential, in addition to sustained release for 6 h. Furthermore, NLCs displayed good storage stability and they were able to increase the skin deposition of melatonin 4.5-folds in stratum corneum, 7-folds in epidermis, and 6.8-folds in the dermis compared to melatonin solution. Melatonin NLCs displayed more clinically desirable results compared to the melatonin solution in AGA patients, manifested by increased hair density and thickness and decreased hair loss. The aforemention...Continue Reading

References

Nov 1, 1975·Southern Medical Journal·O T Norwood
Oct 1, 1988·British Journal of Clinical Pharmacology·F H LeenenW P Unger
Dec 21, 1996·BMJ : British Medical Journal·J G Mosley, A C Gibbs
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W OwenH Bartsch
Mar 4, 2006·Biomaterials·Vaibhav DubeyNarendra Kumar Jain
Mar 12, 2008·Journal of Nanoscience and Nanotechnology·Lorenzo PrianoAlessandro Mauro
Jul 9, 2008·Journal of Microencapsulation·Maha NasrA A Elshamy
Jul 31, 2009·AAPS PharmSciTech·Pankaj Pathak, Mangal Nagarsenker
Aug 12, 2009·Journal of Pharmaceutical Sciences·Biancamaria Baroli
Jan 1, 2009·International Journal of Trichology·Yuval RamotAbraham Zlotogorski
Jul 1, 2009·International Journal of Trichology·Rachita Dhurat, Punit Saraogi
Oct 12, 2011·International Journal of Pharmaceutics·Ana González-ParedesMercedes Monteoliva-Sánchez
Mar 14, 2012·Recent Patents on Inflammation & Allergy Drug Discovery·Alfredo RossiStefano Calvieri
Jun 6, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Surajit DasReginald B H Tan
Jan 8, 2013·International Journal of Nanomedicine·Ch LooYm Choo
Jan 22, 2014·Colloids and Surfaces. B, Biointerfaces·Nisharani S RanpiseVinod N Ghodake
Feb 15, 2014·World Journal of Clinical Cases·Carlton Robert FenzlJason Goldsmith
May 9, 2014·BioMed Research International·Anja Vujovic, Véronique Del Marmol
Dec 5, 2014·International Journal of Nanomedicine·Rehab Nabil Shamma, Mona Hassan Aburahma
Dec 30, 2014·Current Pharmaceutical Biotechnology·Maha Nasr, Sameh Abdel-Hamid
Mar 27, 2015·The Journal of Dermatology·Ruiming HuQinping Yang
Jul 3, 2015·Drug Development and Industrial Pharmacy·Maha Nasr, Sameh Abdel-Hamid
Aug 12, 2015·Indian Journal of Dermatology, Venereology and Leprology·Eman Ahmed BseisoNabaweya A Abd El Gawad
Jan 1, 2014·Antioxidants·Nick Kalogeropoulos, Maria Z Tsimidou
Feb 20, 2016·Pharmaceutical Development and Technology·Maha FadelAbdullah A Alyoussef
Mar 10, 2016·Journal of Liposome Research·Fatma S Abdel-SalamSeham A Elkheshen
May 4, 2016·Colloids and Surfaces. B, Biointerfaces·Mehdi SabzichiOmmoleila Molavi
Aug 9, 2016·Journal of Pineal Research·Russel J ReiterLilian Qin
Feb 25, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rana AbdelgawadManal Yassin Hamza

❮ Previous
Next ❯

Citations

Nov 10, 2018·Expert Opinion on Drug Delivery·Maha NasrAnant Paradkar
Jul 31, 2020·Pharmaceutical Development and Technology·Abdullah AlyoussefAnant Paradkar
Oct 11, 2019·International Journal of Molecular Sciences·Iryna RusanovaGermaine Escames
Nov 24, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nada M El HoffySeham A Elkheshen
Feb 1, 2020·International Journal of Pharmaceutics·Sandra Sherif AmerOmaima Sammour
Apr 25, 2021·Photodiagnosis and Photodynamic Therapy·Maha FadelSarah Salah Thabet
Jun 1, 2021·Dermatologic Clinics·Natalie KashRahil B Roopani
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz Gustavo de Almeida ChuffaRussel J Reiter
Aug 22, 2021·Colloids and Surfaces. B, Biointerfaces·Priya MishraRahul Shukla
Nov 10, 2021·Pharmaceutical Development and Technology·Ghada M El-Zaafarany, Maha Nasr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

© 2022 Meta ULC. All rights reserved