Clinical course and outcome in French adults with Moyamoya disease

Revue neurologique
L CalviereV Larrue


Moyamoya disease is rare among non-Asian populations and its clinical features are ill-defined. We report 12 new cases of Moyamoya disease in French, non-Asian adults. We identified adults with Moyamoya disease managed at a French University Hospital from 1998 through 2006. We reviewed baseline clinical and radiological data and collected follow-up data between March and June 2008. The risk of recurrent stroke was determined using the Kaplan-Meier method. Twelve patients, 10 women and two men, were included. The mean age at baseline was 31.1 years. The initial clinical manifestation was ischemic stroke in 10 patients. The disease was clinically asymptomatic in two patients. The mean follow-up in the 10 symptomatic patients was 52.4 months. Only one patient was surgically treated. The one and five-year risk of recurrent stroke were both 50%. At the end of the follow-up, one patient was dead, four patients had no functional impairment (grade 0-1 on the Rankin scale), and seven patients had moderate functional impairment (grade 2-3 on the Rankin scale). A cognitive dysfunction as identified by failure on the Trail Making Test part B was found in six of ten patients evaluated. Moyamoya disease in this cohort of French, non-Asian ad...Continue Reading


May 1, 1987·Journal of Neurosurgery·M V OldsH Schutz
Jan 1, 1984·European Neurology·W Isler
Jan 1, 1983·Stroke; a Journal of Cerebral Circulation·J Suzuki, N Kodama
Oct 1, 1995·Radiology·I YamadaY Matsushima
Jan 1, 1996·Acta neurochirurgica·S KawaguchiH Iwanaga
Feb 1, 1997·Surgical Neurology·M Fukui
Dec 31, 1997·Clinical Neurology and Neurosurgery·Y NumaguchiD K Shibata
Dec 31, 1997·Clinical Neurology and Neurosurgery·H J Hoffman
Dec 31, 1997·Clinical Neurology and Neurosurgery·L BorotaM Kovacevic
Dec 31, 1997·Clinical Neurology and Neurosurgery·Y YonekawaH G Imhof
Jul 11, 1998·Stroke; a Journal of Cerebral Circulation·D ChiuJ C Grotta
Mar 8, 2000·Neuropediatrics·C ImaizumiM Takeshita
Mar 11, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tom N Tombaugh
May 6, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Peter HornPeter Schmiedek
Jan 13, 2005·Cerebrovascular Diseases·Peter HornMichael Hennerici
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T NariaiK Ohno
Sep 9, 2005·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Gregory J ZipfelDennis J Rivet
Sep 28, 2005·Neurology·Ken UchinoDavid L Tirschwell
Apr 29, 2006·Stroke; a Journal of Cerebral Circulation·Christopher L HallemeierColin P Derdeyn
Nov 23, 2006·Neurosurgical Focus·N M WetjenC M Loftus
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·Shinichi KuriyamaTakashi Yoshimoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.