Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

The Lancet. Respiratory Medicine
Xiaobo YangYou Shang

Abstract

An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in December, 2019, in Wuhan, China. Information about critically ill patients with SARS-CoV-2 infection is scarce. We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. In this single-centered, retrospective, observational study, we enrolled 52 critically ill adult patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital (Wuhan, China) between late December, 2019, and Jan 26, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. Data were compared between survivors and non-survivors. The primary outcome was 28-day mortality, as of Feb 9, 2020. Secondary outcomes included incidence of SARS-CoV-2-related acute respiratory distress syndrome (ARDS) and the proportion of patients requiring mechanical ventilation. Of 710 patients with SARS-CoV-2 pneumonia, 52 critically ill adult patients were included. The mean age of the 52 patients was 59·7 (SD 13·3) years, 35 (67%) were men, 21 (40%) had chronic illness, 51 (98%) had fever. 32 (61·5%) patien...Continue Reading

Associated Clinical Trials

Mar 25, 2020·Klinik für Kardiologie, Pneumologie und Angiologie
Apr 24, 2020·Philippe Jouvet
Apr 27, 2020·Oscar Gerardo Arrieta Rodríguez
May 8, 2020·Alessandra Del Felice
Aug 11, 2020·EDUARDO CHUQUIURE-VALENZUELA MD MSc FACC

Citations

Mar 4, 2020·Intensive Care Medicine·Yaseen M ArabiSteve Webb
Mar 12, 2020·JAMA : the Journal of the American Medical Association·Srinivas MurthyRobert A Fowler
Mar 14, 2020·Emerging Infectious Diseases·Nick WilsonMichael G Baker
Mar 31, 2020·Alimentary Pharmacology & Therapeutics·Yuan TianYan He
Apr 3, 2020·Journal of Clinical Medicine·Israel Júnior Borges do NascimentoMilena Soriano Marcolino
Apr 3, 2020·Frontiers of Medicine·Min ZhouJieming Qu
Mar 29, 2020·Journal of Medical Virology·Cantong ZhangYong Dai
Apr 9, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Wuelton Marcelo MonteiroMarcus Vinicius Guimarães Lacerda
Apr 11, 2020·Tissue Engineering. Part a·Alexander M Tatara
Apr 16, 2020·Critical Care : the Official Journal of the Critical Care Forum·Yingchun ZengQiaoyuan Yan
Mar 28, 2020·Journal of Gastroenterology and Hepatology·Sunny H WongJoseph Jy Sung
Apr 28, 2020·Head & Neck·Flora Yan, Shaun A Nguyen
Apr 28, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Linda Y Tang, Jingping Wang
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 29, 2020·Journal of Primary Care & Community Health·Zach Sartor, Burritt Hess
May 1, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Himanshu SankrityayanAnil Bhanudas Gaikwad
Mar 15, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Ling XuXin Zheng
May 1, 2020·European Heart Journal. Acute Cardiovascular Care·Niel HensGeert Molenberghs
Apr 25, 2020·Head & Neck·Cameron P HeydTerry A Day
Apr 3, 2020·Journal of Medical Virology·Qing YeTing Zhang
Apr 18, 2020·Journal of Thrombosis and Haemostasis : JTH·Xiaobo YangYou Shang
May 5, 2020·Microbial Biotechnology·Harald Brüssow
Mar 26, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Zaid A AbassiZaher Armaly
Apr 9, 2020·Pharmacotherapy·Kathleen A StringerRobert P Dickson
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Apr 13, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·TieLong ChenYong Xiong
May 10, 2020·Stem Cells and Development·Vikram SenguptaNicholas Bremer
Apr 9, 2020·International Journal of Clinical Practice·Richard Albert Stein
Apr 9, 2020·Journal of Thrombosis and Haemostasis : JTH·Janice WangChristopher D Barrett
May 6, 2020·Journal of Medical Virology·Yueying Li, Shu-Yuan Xiao
Apr 30, 2020·Journal of Internal Medicine·Giuseppe PascarellaFelice Eugenio Agrò
Apr 9, 2020·The Medical Journal of Australia·Lei ZhaElmer V Villanueva

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NCT04252664
NCT04257656
NCT04244591

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IC
Stata

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