Clinical course and prognosis of childhood epilepsy

Acta Paediatrica Japonica; Overseas Edition
E OkaS Ohtahara

Abstract

Remarkable progress has been accomplished in epileptology in recent years. The remission rate in childhood epilepsy has been improved by the introduction of new technologies and better diagnostic as well as therapeutic methods. Investigation of prognosis is an important field of epileptology, because prognostic improvement reflects its overall progress. A long-term follow-up study of childhood epilepsy was undertaken in the Okayama University Hospital. Ten to 15 years of follow-up was possible in 730 of 1,295 patients who were first diagnosed at ages below 15 years, from 1968 to 1971. The 3-year remission rate amounted to 82.0% and 5-year remission was obtained in 79.1%. These high rates of remission indicate the favorable prognosis of childhood epilepsy. On the other hand, cases of intractable epilepsy also amounted to a considerable number. Intractable epilepsy consisted mainly of age-dependent epileptic encephalopathy (Ohtahara's syndrome, West syndrome and Lennox-Gastaut syndrome) and severe myoclonic epilepsy in infancy. Development of effective therapy for these intractable epileptic syndromes will be an important subject of future studies.

References

Dec 1, 1979·Epilepsia·J F AnnegersL R Elveback
Oct 11, 1984·The New England Journal of Medicine·R D ElwesE H Reynolds

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Citations

Aug 28, 1999·Pediatric Neurology·M SillanpääS Shinnar
Jan 29, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M A Fernández FernándezR Mateos Checa
Sep 21, 2016·Seizure : the Journal of the British Epilepsy Association·M Sillanpää, D Schmidt
May 1, 1996·Journal of Child Neurology·E HauserC Groh
Jan 1, 1992·Journal of Child Neurology·J F Donat
Jun 1, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S Wiebe

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