Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.

Lancet
Fei ZhouBin Cao

Abstract

Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), fo...Continue Reading

Associated Clinical Trials

May 13, 2021·Mak Wing Yan, Mak Wing Yan
Apr 20, 2020·Gian Paolo Rossi, MD, FAHA, FACC

Citations

Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 31, 2020·Alimentary Pharmacology & Therapeutics·Yuan TianYan He
Apr 7, 2020·Pediatric Pulmonology·Daniele CanaruttoGraziano Barera
Mar 21, 2020·Allergy·Xiang DongYa-Dong Gao
Apr 8, 2020·Circulation Research·Akbarshakh Akhmerov, Eduardo Marban
Apr 9, 2020·Journal of Gerontological Nursing·Heather M Young, Donna M Fick
Apr 9, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Wuelton Marcelo MonteiroMarcus Vinicius Guimarães Lacerda
Apr 11, 2020·The New England Journal of Medicine·Jonathan GreinTimothy Flanigan
Apr 10, 2020·Journal of Cardiovascular Electrophysiology·Adriano Nunes KochiClaudio Tondo
Apr 14, 2020·JAMA : the Journal of the American Medical Association·James M SandersJames B Cutrell
Apr 14, 2020·Annals of Internal Medicine·Matthew P ChengCedric P Yansouni
Apr 7, 2020·Journal of Medical Virology·Mushtaq HussainBasma Aziz
Apr 16, 2020·Circulation·Peter P LiuHongliang Li
Apr 4, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ivan BerlinJacques Cornuz
Apr 5, 2020·Journal of Clinical Medicine·Pietro H GuzziFederico M Giorgi
Apr 7, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Stella M PapaUNKNOWN MDS-Scientific Issues Committee
Apr 17, 2020·JAMA Internal Medicine·Michael A SteinmanCarla M Perissinotto
Apr 18, 2020·Cardiovascular Research·Eleanor MurrayTomasz J Guzik
Apr 18, 2020·Facial Plastic Surgery & Aesthetic Medicine·Tsung-Yen HsiehPeter A Hilger
Mar 28, 2020·Journal of Gastroenterology and Hepatology·Sunny H WongJoseph Jy Sung
Apr 22, 2020·Age and Ageing·Hui Sian Tay, Rowan Harwood
Mar 27, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Molly SzerlipSrihari S Naidu
Apr 18, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Peter A KavsakAndrew Worster
Apr 23, 2020·Journal of the American Society of Nephrology : JASN·UNKNOWN Columbia University Kidney Transplant Program
Apr 23, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Parham SadeghipourSeifollah Abdi
Apr 23, 2020·Cadernos de saúde pública·Leonardo Soares BastosMarcelo F C Gomes
Apr 24, 2020·Future Oncology·Elie RassyJoseph Kattan
Apr 25, 2020·The New England Journal of Medicine·Rajesh T GandhiCarlos Del Rio
Apr 25, 2020·JAMA : the Journal of the American Medical Association·John J Marini, Luciano Gattinoni
Apr 25, 2020·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Sami Al KasabChristine A Holmstedt
Apr 25, 2020·Microorganisms·Ana C MoreiraMaria Salomé Gomes
Apr 28, 2020·Head & Neck·Flora Yan, Shaun A Nguyen
Apr 16, 2020·Journal of Medical Virology·Adam Brufsky
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network

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Methods Mentioned

BETA
bronchoalveolar
lavage

Clinical Trials Mentioned

NCT04257656
NCT04252664

Software Mentioned

SAS

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