Abstract
Despite the frequency of use of citalopram, its clinical effects and pharmacokinetics in overdose in the pediatric patient are not well described. We describe the clinical course and drug levels following the ingestion of citalopram by a 10-month-old female. A 10 month-old female ingested an unknown amount of citalopram. Approximately 40 min after ingestion, the child developed horizontal nystagmus, followed by a generalized, tonic-clonic seizure that lasted 2 to 3 min very shortly thereafter. The child received 1 mg of midazolam intramuscularly (IM), followed by 1 mg of midazolam intravenously (IV) for termination of this seizure, and was given a loading dose of 20 mg/kg of fosphenytoin IV. Elective orotracheal intubation was done to protect the airway. Despite the use of midazolam and fosphenytoin, the child had another seizure approximately 85 min following the ingestion. A third seizure was noted at approximately 100 min post-ingestion. In the course of treatment, activated charcoal was administered via nasogastric tube, and IV midazolam and phenobarbital were given. The child was transferred to a nearby facility with pediatric intensive care capabilities in stable condition. The child did not experience any hypotension or ...Continue Reading
References
Nov 9, 1978·European Journal of Clinical Pharmacology·K F Overø
Mar 1, 1991·Drugs·R J Milne, K L Goa
Jun 8, 1984·Journal of Chromatography·E OyehaugB Salvesen
Jan 1, 1981·Acta Pharmacologica Et Toxicologica·P Kragh-SørensenW Parnas
Mar 1, 1982·Acta Pharmacologica Et Toxicologica·V BoeckO Svendsen
Aug 1, 1994·The Journal of Antimicrobial Chemotherapy·P A Routledge
Jan 1, 1993·European Journal of Clinical Pharmacology·D BaettigP Baumann
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·M PersonneH Persson
Sep 23, 1997·Lancet·A H Glassman
Apr 18, 2000·Emergency Medicine Clinics of North America·J F Goldberg
Aug 25, 2000·Pharmacopsychiatry·H B RothenhäuslerM M Weber
Dec 29, 2000·Pharmacotherapy·M Gutierrez, W Abramowitz
Jun 8, 2001·Clinical Neuropharmacology·G CatalanoP E Tsambiras
Apr 10, 2002·Pharmacotherapy·Larry A DentJenny D Murney
Apr 16, 2003·Human & Experimental Toxicology·C A KellyD N Bateman
Aug 7, 2003·The Journal of Emergency Medicine·Kristin M EngebretsenJames E Wood
Feb 26, 2004·The Journal of Emergency Medicine·Peter John CuencaJeffrey David Hoefle
Apr 16, 2004·Journal of Toxicology. Clinical Toxicology·C A KellyD N Bateman
Citations
Jul 23, 2013·The Journal of Emergency Medicine·Derrick D LungRoy R Gerona
Nov 27, 2008·British Journal of Clinical Pharmacology·W Stephen WaringAnn Graham
Sep 22, 2012·European Journal of Clinical Pharmacology·M J Cooke, W S Waring
Dec 9, 2020·BMC Pediatrics·Jo-Anne JansonMarieke Kerskes