PMID: 16615673Apr 18, 2006Paper

Clinical course and toxicokinetic data following isolated citalopram overdose in an infant

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Lawrence N MasulloMarc Levsky

Abstract

Despite the frequency of use of citalopram, its clinical effects and pharmacokinetics in overdose in the pediatric patient are not well described. We describe the clinical course and drug levels following the ingestion of citalopram by a 10-month-old female. A 10 month-old female ingested an unknown amount of citalopram. Approximately 40 min after ingestion, the child developed horizontal nystagmus, followed by a generalized, tonic-clonic seizure that lasted 2 to 3 min very shortly thereafter. The child received 1 mg of midazolam intramuscularly (IM), followed by 1 mg of midazolam intravenously (IV) for termination of this seizure, and was given a loading dose of 20 mg/kg of fosphenytoin IV. Elective orotracheal intubation was done to protect the airway. Despite the use of midazolam and fosphenytoin, the child had another seizure approximately 85 min following the ingestion. A third seizure was noted at approximately 100 min post-ingestion. In the course of treatment, activated charcoal was administered via nasogastric tube, and IV midazolam and phenobarbital were given. The child was transferred to a nearby facility with pediatric intensive care capabilities in stable condition. The child did not experience any hypotension or ...Continue Reading

References

Nov 9, 1978·European Journal of Clinical Pharmacology·K F Overø
Jan 1, 1981·Acta Pharmacologica Et Toxicologica·P Kragh-SørensenW Parnas
Mar 1, 1982·Acta Pharmacologica Et Toxicologica·V BoeckO Svendsen
Aug 1, 1994·The Journal of Antimicrobial Chemotherapy·P A Routledge
Jan 1, 1993·European Journal of Clinical Pharmacology·D BaettigP Baumann
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·M PersonneH Persson
Sep 23, 1997·Lancet·A H Glassman
Apr 18, 2000·Emergency Medicine Clinics of North America·J F Goldberg
Dec 29, 2000·Pharmacotherapy·M Gutierrez, W Abramowitz
Apr 10, 2002·Pharmacotherapy·Larry A DentJenny D Murney
Apr 16, 2003·Human & Experimental Toxicology·C A KellyD N Bateman
Aug 7, 2003·The Journal of Emergency Medicine·Kristin M EngebretsenJames E Wood
Feb 26, 2004·The Journal of Emergency Medicine·Peter John CuencaJeffrey David Hoefle
Apr 16, 2004·Journal of Toxicology. Clinical Toxicology·C A KellyD N Bateman

❮ Previous
Next ❯

Citations

Jul 23, 2013·The Journal of Emergency Medicine·Derrick D LungRoy R Gerona
Nov 27, 2008·British Journal of Clinical Pharmacology·W Stephen WaringAnn Graham
Sep 22, 2012·European Journal of Clinical Pharmacology·M J Cooke, W S Waring
Dec 9, 2020·BMC Pediatrics·Jo-Anne JansonMarieke Kerskes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
D S Dorasamy
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
A BoucherJ Descotes
Indian Journal of Dermatology, Venereology and Leprology
K Krishna, S Misra
Indian Journal of Pediatrics
Bhanu Kiran Bhakhri, Pradeep K Debata
© 2022 Meta ULC. All rights reserved