Clinical course in patients with chronic carbon disulfide polyneuropathy

Clinical Neurology and Neurosurgery
Chin-Chang HuangNai-Shin Chu

Abstract

The natural course of clinical manifestations and electrophysiological changes were studied in six patients with carbon disulfide (CS(2)) induced polyneuropathy. All of the six patients worked in the cutting-machine department of a viscose rayon plant. The environmental monitoring was also conducted in the initial stage and followed up 3 years later. In the 3-year follow-up period, the neurological symptoms and signs persisted. The highest concentration of CS(2) in the cutting machine where these patients worked was about 100-200 ppm. Three years later, the highest concentration was decreased to between 10 and 20 ppm in the cutting machine of the new production line after the engineering control had been improved. Nerve conduction velocity (NCV) studies revealed persistent abnormality in motor and sensory NCVs. Although, a tendency to improvement was noted, it did not reach a statistical significance except for conduction velocity of sural nerve in sensory NCV. Sural nerve biopsy from one patient, 2 years after diagnosis showed degeneration of both axon and myelin and a predominant loss of large myelinated fibers. A remyelination process was also noted. We concluded that CS(2) intoxication may induce a persistent damage to the ...Continue Reading

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Citations

Jul 23, 2011·The International Journal of Neuroscience·Ning DingZhenzhong Li
Dec 7, 2006·Neurotoxicology·Wen-Li ChuangTung-Sheng Shih
Mar 1, 2006·International Journal of Hygiene and Environmental Health·Lode GodderisMineke Viaene
Jul 5, 2005·Toxicology Letters·Gabriella CalvielloTommaso Galeotti
Mar 11, 2005·Neurologic Clinics·Patrick M Grogan, Jonathan S Katz
Dec 16, 2006·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jessica WylieDave Nicolle
Jan 24, 2017·Journal of Occupational Health·Noriyuki YoshiokaKazuyuki Omae

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