Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Marcelo M AbrantesEduardo A Oliveira

Abstract

The purpose of this retrospective cohort study was to report the clinical course of children and adolescents with primary focal segmental glomerulosclerosis (FSGS). The records of 110 patients with biopsy-proven FSGS admitted between 1972 and 2004 were retrospectively reviewed. Demographic, clinical and laboratory data were recorded and histopathological data were reanalyzed by one pathologist who had no information about the outcome of the patients. Renal survival analysis was performed using the Kaplan-Meier method. Differences between subgroups (response to corticosteroids) were assessed by the two-sided log rank test. The median age at admission was 5 years (range: 1-15 years). Forty-two patients (38.2%) presented with hematuria at admission, and 55 (50%) presented blood pressure levels above the 95th percentile. Mean follow-up time was 10 years (SD 5.5). Twenty-four patients (21.8%) presented chronic kidney disease (CKD). It was estimated that the probability of CKD was 8% at 5 years, 17% at 10 years, and 32% at 15 years after diagnosis of nephrotic syndrome. In conclusion, on the basis of the clinical and histological characteristics observed, apparently our cohort of idiopathic FSGS is comparable with other published ser...Continue Reading

References

Nov 1, 1978·The Journal of Pediatrics·D EllisE J Yunis
Mar 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A Tufro-McReddieH Repetto
Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E Ingulli, A Tejani
Jul 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S A MendozaB M Tune
Jul 1, 1986·The Journal of Pediatrics·N YoshikawaT Matsuo
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HaasS Coventry
Oct 1, 1994·Kidney International·V D'Agati
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M KorbetE J Lewis
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I Ichikawa, A Fogo
Jun 30, 1998·Journal of the American Society of Nephrology : JASN·S M Korbet
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D C Cattran, P Rao
Jan 5, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J M SorofD R Powell
Apr 1, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T SrivastavaU S Alon
May 7, 1999·Kidney International·M Bonilla-FelixR Verani
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·M M SchwartzS M Korbet
Sep 7, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S GulatiR K Gupta
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E AlexopoulosM Papadimitriou
Aug 25, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R MartinelliH Rocha
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Flavia C ParraSérgio D J Pena
Apr 22, 2003·Seminars in Nephrology·H William Schnaper
May 17, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Teresinha L DonattiYassuhiko Okay
Aug 29, 2003·Lancet·Allison A Eddy, Jordan M Symons
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Rainer G RufUNKNOWN Arbeitsgemeinschaft Für Pädiatrische Nephrologie Study Group
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Micky J ChunEdmund J Lewis
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents

❮ Previous
Next ❯

Citations

Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marcelo M AbrantesEduardo A Oliveira
Oct 24, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kyung Hoon PaikYong Choi
Mar 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M Hodson, Jonathan C Craig
Mar 3, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ahmed M El-RefaeyAmr Sarhan
Feb 16, 2008·Current Opinion in Nephrology and Hypertension·Martin R Pollak
Aug 19, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maja ŽivotićJasmina Marković-Lipkovski
Mar 8, 2014·Advances in Chronic Kidney Disease·Christine B Sethna, Debbie S Gipson
Jul 3, 2013·Néphrologie & thérapeutique·Samira TizkiMohammed Itri
Feb 28, 2015·Renal Failure·Mayuri TrivediRajendra Pandey
Jan 13, 2015·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Guditi SwarnalathaK V Dakshinamurty
Oct 30, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Silvania França da Silva SoaresFrancisco José Dutra Souto
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Douglas M Silverstein, Randall Craver
May 26, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alanoud AlshamiUNKNOWN Pediatric Nephrology Clinical Pathway Development Team

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Marcelo M AbrantesEduardo A Oliveira
Clinical Journal of the American Society of Nephrology : CJASN
Douglas M Silverstein, Randall Craver
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Ahmed M El-RefaeyAmr Sarhan
World Journal of Pediatrics : WJP
Lori L Travis, James C M Chan
Clinical Journal of the American Society of Nephrology : CJASN
Sundararaman SwaminathanFernando C Fervenza
© 2021 Meta ULC. All rights reserved