Clinical course of autoimmune hemolytic anemia: an observational study

Jornal de pediatria
Maria Christina L A OliveiraMarcos B Viana

Abstract

Autoimmune hemolytic anemia is characterized by the production of autoantibodies against erythrocyte membrane antigens. This study was carried out to identify the clinical, immunological and outcome characteristics of autoimmune hemolytic anemia patients treated at the (HC-UFMG) Pediatric Hematology Unit and the Hemocentro de Belo Horizonte. We evaluated 17 patients younger than 15 years old admitted from 1988 to 2003 were evaluated. Autoimmune hemolytic anemia diagnosis was based on the presence of acquired hemolysis and confirmed by positive direct Coombs polyspecific test results. Clinical, laboratory, and outcome data were obtained from patient records. The median age at diagnosis was 10.5 months. The direct Coombs polyspecific test was positive in 13 and negative in four patients. Monospecific testing was performed for 14 patients. The most frequent red cell autoantibody was IgG (five patients), followed by IgM in two. Thirteen patients had severe anemia and needed blood transfusions. Underlying diseases were identified in four patients: systemic lupus erythematosus, Hodgkin's lymphoma, autoimmune hepatitis and Langerhans cell histiocytosis. The remaining patients were classified as having primary disease. The median follo...Continue Reading

Citations

Jan 14, 2011·Haematologica·Nathalie AladjidiUNKNOWN Centre de Référence National des Cytopénies Auto-immunes de l'Enfant (CEREVANCE)
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Jason Elliott HorganThomas Schermerhorn
Apr 4, 2021·Journal of Clinical Medicine·Stinne TranekærHenrik Frederiksen

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