Abstract
Epidemiology of patients with worsening heart failure and reduced ejection fraction (HFrEF) in the real-world setting is not well described. The purpose of this study was to describe incidence, clinical characteristics, treatment, and outcomes of patients with HFrEF who develop worsening heart failure (HF) in the real-world setting. Data on patients with incident HFrEF from the National Cardiovascular Data Registry PINNACLE were linked to pharmacy, private practitioner, and hospital claims databases. Incidence, clinical characteristics, treatment (angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, beta-blocker, and mineralocorticoid receptor antagonist) and outcomes of patients with worsening HF, defined as ≥90 days of stable HF with subsequent worsening requiring intravenous diuretic agents, were assessed. Of 11,064 HFrEF patients, 1,851 (17%) developed worsening HF on average 1.5 years following initial HF diagnosis. Patients who developed worsening HF were more likely to be African American, be octogenarians, and have higher comorbidity burden (p < 0.001). At the onset of worsening HF, 42.4% of patients were on monotherapy, 43.4% were on dual therapy, and 14.1% were on triple therapy. A total of 48%, 61%, ...Continue Reading
Citations
May 22, 2019·PLoS Medicine·Mohamed S AnwarNicholas L Mills
Jun 21, 2019·ESC Heart Failure·Michael J DiamantNathaniel M Hawkins
Sep 10, 2019·European Journal of Heart Failure·Peder L MyhreMuthiah Vaduganathan
Jan 28, 2020·The Journal of the American Osteopathic Association·Felix J Rogers, Zeinab Saghir
Mar 12, 2020·ESC Heart Failure·Eric WierdaJutta Maria Schroeder-Tanka
Aug 20, 2019·Circulation·Ely GraciaJaved Butler
May 6, 2020·ESC Heart Failure·Alexandra ArvanitakiGeorge Giannakoulas
Jul 15, 2020·Journal of the American Heart Association·Muhammad Shahzeb KhanStephen J Greene
Aug 8, 2020·Advances in Therapy·Javed ButlerMei Yang
May 7, 2020·European Journal of Heart Failure·Muhammad Shahzeb KhanStephen J Greene
Mar 30, 2020·The New England Journal of Medicine·Paul W ArmstrongUNKNOWN VICTORIA Study Group
Oct 9, 2020·Clinical Pharmacokinetics·Michael BoettcherCorina Becker
Jan 21, 2021·Heart Failure Reviews·Stephen J GreeneJaved Butler
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 18, 2021·JACC. Cardiovascular Imaging·Grigorios KorosoglouHenning Steen
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Nathan EngstromHayley L Letson
Dec 9, 2020·Journal of Cardiac Failure·Stephen J GreeneUNKNOWN Heart Failure Society of America Quality of Care Committee
Mar 11, 2021·ESC Heart Failure·Michael M GivertzJaved Butler
Apr 15, 2021·The New England Journal of Medicine·Deepak L BhattBertram Pitt
Apr 17, 2021·Advances in Therapy·Adnan AlsumaliLaurence M Djatche
Apr 15, 2021·The New England Journal of Medicine·Piero Baglioni
Apr 27, 2021·Journal of Medical Economics·Robert J MentzLaurence M Djatche
Apr 27, 2021·Journal of the Chinese Medical Association : JCMA·Huai-Wen LiangHung-Yu Chang
Jun 3, 2021·Expert Opinion on Pharmacotherapy·Jean-Sébastien HulotYves Juillière
May 11, 2020·JACC. Heart Failure·Muthiah VaduganathanJaved Butler
Jun 5, 2021·Clinical Pharmacokinetics·Hauke RuehsMichaela Meyer
Dec 15, 2020·JACC. Heart Failure·Ersilia M DeFilippis, Mona Fiuzat
May 17, 2021·JACC. Heart Failure·Tariq AhmadF Perry Wilson
May 31, 2021·European Journal of Heart Failure·Javed ButlerLaurence M Djatche
Jun 26, 2021·The American Journal of Cardiology·Dennis GrewalDmitry Abramov
May 18, 2021·European Journal of Heart Failure·Vasiliki BistolaGerasimos Filippatos
Jul 5, 2021·Journal of Cardiac Failure·Robert J MentzUNKNOWN VICTORIA Study Group
Jul 17, 2021·Journal of Cardiac Failure·Javed ButlerRobert J Mentz
Jul 31, 2021·ESC Heart Failure·Chia-Te LiaoHung-Yu Chang
Aug 9, 2021·Journal of Cardiac Failure·Sandra B DunbarJohn A Spertus
Jun 30, 2021·European Journal of Heart Failure·Stephen J Greene, Gregg C Fonarow
Aug 20, 2021·Journal of Taibah University Medical Sciences·Yoga WaranugrahaIndra J Aziz
Aug 26, 2021·The Annals of Pharmacotherapy·Nicole CampbellKathleen Frey
Oct 9, 2021·PharmacoEconomics·Adnan AlsumaliDominik Lautsch
Oct 10, 2021·European Heart Journal. Quality of Care & Clinical Outcomes·Anojhaan ArulmurugananthavadivelMorten Schou
Aug 18, 2020·JACC. Heart Failure·Stephen J GreeneLei Chen
Dec 18, 2021·ESC Heart Failure·James L JanuzziDominik Lautsch
Jan 22, 2022·Kardiologiia·S V Villevalde, A E Soloveva