Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis

BMJ : British Medical Journal
Karoliina TainioIlkka E J Kalliala

Abstract

To estimate the regression, persistence, and progression of untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions managed conservatively as well as compliance with follow-up protocols. Systematic review and meta-analysis. Medline, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) from 1 January 1973 to 20 August 2016. Studies reporting on outcomes of histologically confirmed CIN2 in non-pregnant women, managed conservatively for three or more months. Two reviewers extracted data and assessed risk of bias. Random effects model was used to calculate pooled proportions for each outcome, and heterogeneity was assessed using I2statistics. Rates of regression, persistence, or progression of CIN2 and default rates at different follow-up time points (3, 6, 12, 24, 36, and 60 months). 36 studies that included 3160 women were identified (seven randomised trials, 16 prospective cohorts, and 13 retrospective cohorts; 50% of the studies were at low risk of bias). At 24 months, the pooled rates were 50% (11 studies, 819/1470 women, 95% confidence interval 43% to 57%; I2=77%) for regression, 32% (eight studies, 334/1257 women, 23% to 42%; I2=82%) for persistence, and 18% (nine studies, 282/1445 wo...Continue Reading

Citations

Jul 29, 2018·BMJ Evidence-based Medicine·Lars JørgensenTom Jefferson
Jan 19, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Kate CuschieriSuzie Coughlan
Jan 29, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Clare A AitkenInge M C M de Kok
Feb 9, 2019·International Journal of Cancer. Journal International Du Cancer·Madleen OrumaaMari Nygård
Jul 5, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ester MiralpeixGemma Mancebo
Sep 27, 2019·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Yasmina OkanWändi Bruine de Bruin
Jan 22, 2020·Journal of the Royal Society of Medicine·Claire P ReesAllyson M Pollock
Dec 28, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·M SkorstengaardG Napolitano
Jul 26, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karolina LouvantoAttila Lorincz
Jul 31, 2020·CA: a Cancer Journal for Clinicians·Elizabeth T H FonthamRobert A Smith
Nov 14, 2019·Archives of Pathology & Laboratory Medicine·Philip E CastleUNKNOWN p16 IHC Study Panel
Aug 25, 2018·JAMA Otolaryngology-- Head & Neck Surgery·Brooke NickelKirsten McCaffery
Dec 24, 2018·Journal of the National Cancer Institute·Philip E CastleMark Schiffman
Mar 12, 2020·Journal of Cancer Research and Clinical Oncology·Tilman L R VogelsangAurelia Vattai
Jul 1, 2020·Cancers·Annu HeinonenIlkka Kalliala
Apr 4, 2020·Journal of Lower Genital Tract Disease·Rebecca B PerkinsUNKNOWN 2019 ASCCP Risk-Based Management Consensus Guidelines Committee
May 13, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Margot M KoenemanArnold J Kruse
Jan 20, 2019·Der Pathologe·D Schmidt
Mar 30, 2020·American Journal of Clinical Pathology·R Marshall Austin, Chenquan Zhao
Apr 24, 2020·Archives of Gynecology and Obstetrics·Donata GrimmLinn Woelber
Oct 9, 2020·Acta Oncologica·Gry St-MartinElsebeth Lynge
Nov 12, 2020·Archives of Gynecology and Obstetrics·Jean-Luc BrunIsabelle Garrigue
Nov 26, 2020·JAMA Otolaryngology-- Head & Neck Surgery·Kirsten J McCaffery, Brooke Nickel
Aug 4, 2020·Journal of the National Cancer Institute·Paolo Giorgi RossiUNKNOWN the New Technology for Cervical Cancer 2 Working Group
Nov 16, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Youn Jin ChoiJong Sup Park
Dec 31, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hongyan RenSuzhen Fan
Oct 15, 2018·Preventive Medicine·Philip E CastleMark Schiffman
May 29, 2019·Journal of Lower Genital Tract Disease·Rebecca B PerkinsL Stewart Massad
Sep 30, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Catriona BuickRachel Kupets
Oct 3, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christine ColieSeble G Kassaye

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.