Clinical courses of chronic hepatitis B virus infection and inflammatory bowel disease in patients with both diseases

Inflammatory Bowel Diseases
Sang Hyoung ParkJin-Ho Kim

Abstract

Little is known about the clinical features of hepatitis B virus (HBV) infection in patients with inflammatory bowel disease (IBD). We therefore evaluated the influence of immunosuppressive treatment for IBD on the course of HBV infection and the effect of HBV infection on the therapeutic strategy and clinical course of IBD patients. We retrospectively evaluated the incidence of and risk factors for liver dysfunction in hepatitis B surface antigen (HBsAg)-positive IBD patients. Also, the clinical course of IBD patients with HBV infection was compared with matched IBD controls without HBV infection. Of 4153 patients diagnosed with IBD between July 1989 and May 2011, 134 were HBsAg-positive, including 54 with Crohn's disease (CD) and 80 with ulcerative colitis (UC). Liver dysfunction was observed in 23 of the 134 (17.2%) HBsAg-positive patients. Prolonged immunosuppression (>3 months) was an independent predictor of liver dysfunction (odds ratio [OR] 3.06; 95% confidence interval [CI] 1.02-9.16). The rate of use of immunosuppressants, including corticosteroids (P = 0.005), azathioprine/6-mercaptopurine (P < 0.001), and infliximab (P = 0.026), was significantly lower in HBsAg-positive than HBsAg-negative IBD patients. Clinical out...Continue Reading

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Citations

Mar 13, 2014·Journal of Crohn's & Colitis·J F RahierUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Mar 30, 2013·World Journal of Gastroenterology : WJG·Pilar López-SerranoMaria Dolores Sánchez-Tembleque
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Feb 1, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang Hwan ChoiUNKNOWN IBD Study Group of the Korean Association for the Study of the Intestinal Diseases
Mar 7, 2017·The Journal of Infection·Giovanni MazzolaAmbrogio Orlando
Jan 29, 2013·Inflammatory Bowel Diseases·Joseph A GordonMarie L Borum
Aug 15, 2019·Journal of Gastroenterology and Hepatology·Kwangwoo NamSuk-Kyun Yang
Feb 28, 2017·Intestinal research·Chang Hwan ChoiUNKNOWN IBD Study Group of the Korean Association for the Study of Intestinal Diseases
Feb 6, 2020·Intestinal research·Soo-Kyung ParkUNKNOWN IBD Research Group of the Korean Association for the Study of Intestinal Diseases
Aug 10, 2018·Intestinal research·Seong Jae YeoUNKNOWN Crohn's and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Mar 9, 2019·Journal of Gastroenterology and Hepatology·Choon Jin OoiUNKNOWN Asia-Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for
Dec 20, 2019·Expert Review of Clinical Immunology·Ying-Ming Chiu, Der-Yuan Chen
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Aug 10, 2021·World Journal of Gastroenterology : WJG·Vincenzo CraviottoMariangela Allocca

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