Clinical courses of schizophrenia

Pharmacopsychiatry
M Albus

Abstract

Schizophrenia is a complex disorder, characterized by molecular, neuroendocrine, and behavioral alterations as well as gene-environment interactions. This article summarizes key facts on the diagnosis, long-term course and neurocognitive deficits of schizophrenia. Due to the heterogeneity of schizophrenia with regard to symptomatology, illness manifestations, course and outcome, the focus of attention has shifted from diagnostic categories to endophenotypes which are hoped to characterize distinct subtypes of schizophrenia more appropriately than the diagnostic classification systems. The systems approach aims to assess the complexity and multiple dynamics of biological systems to explain endophenotypes of schizophrenia and their associations with susceptibility genes. Data presented in this paper support the view that looking for associations between neurocognitive endophenotypes and susceptibility genes might be a promising approach for future research to elucidate the heterogeneity of schizophrenic spectrum disorders.

Citations

May 8, 2013·Journal of Child and Adolescent Psychopharmacology·Daniel J SaferAlan M Safer
Sep 21, 2012·Current Opinion in Psychiatry·Stefan SchwarzAlistair Burns
Jul 25, 2013·Current Opinion in Psychiatry·Sarah C E Chapman, Rob Horne
Apr 4, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Milan GrundmannRomana Urinovska
Feb 26, 2016·Frontiers in Cellular Neuroscience·Katarina DavalievaAndrew J Dwork
Apr 8, 2016·International Journal of Psychiatry in Clinical Practice·Stefano PorcelliAlessandro Serretti
Apr 2, 2014·Journal of Psychiatric Research·Carissa L Philippi, Michael Koenigs
Aug 11, 2020·Schizophrenia Research and Treatment·Jingchun ChenXiangning Chen

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