Clinical Cutaneous Features of Patients Infected With SARS-CoV-2 Hospitalized for Pneumonia: A Cross-sectional Study.

Open Forum Infectious Diseases
Hélène MascittiIsabelle Bourgault-Villada

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients. We performed a cross-sectional study on 1 given day among all patients hospitalized in acute care for COVID-19 and included all patients with cutaneous features. Follow-up 48 hours later was obtained. Among 59 adult patients hospitalized on the day of the study in an infectious diseases ward for SARS-CoV-2 infection who were confirmed by molecular assay and/or radiological findings (computed tomography scan), 40 were included. Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17 patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak. Various dermatological signs can be encountered during COVID-19. A macular rash...Continue Reading

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Citations

Feb 24, 2021·Journal of Travel Medicine·Benjamin DavidoPierre de Truchis
Apr 4, 2021·Dermatology and Therapy·Paolo GisondiLuigi Naldi
Jul 14, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Hélène MascittiUNKNOWN AP-HP/Universities/INSERM COVID-19 research collaboration

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Methods Mentioned

BETA
biopsy
biopsies

Clinical Trials Mentioned

NCT04364698
NCT04324073

Software Mentioned

Statistical Package for Social Science

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