Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.

Blood
Sonali M SmithRichard A Larson

Abstract

Therapy-related myelodysplasia and myeloid leukemia (t-MDS/t-AML) is a distinctive clinical syndrome occurring after exposure to chemotherapy (CT) or radiotherapy (RT). We report findings on 306 consecutive patients referred to our institution with morphologic review and cytogenetic analyses. Since 1972, 141 males and 165 females with a median age of 51 years (range, 3-83 years) at primary diagnosis and 58 years (range, 6-86 years) at secondary diagnosis were analyzed. Patients had been administered various cytotoxic agents, including alkylating agents (240 patients, 78%) and topoisomerase 2 inhibitors (115 patients, 39%). One hundred twenty-one (40%) had undergone CT alone, 43 (14%) had undergone RT alone, and 139 (45%) had undergone both modalities. At diagnosis of t-MDS/t-AML, 282 (92%) had clonal abnormalities involving chromosome 5 (n = 63), chromosome 7 (n = 85), chromosomes 5 and 7 (n = 66), recurring balanced rearrangements (n = 31), other clonal abnormalities (n = 39), or normal karyotype (n = 24). Abnormalities of chromosome 5, 7, or both accounted for 76% of all cases with an abnormal karyotype. Seventeen patients acquired t-MDS/t-AML after autologous stem cell transplantation, but no unique pattern of cytogenetic ab...Continue Reading

References

Jul 1, 1978·Cancer·James W VardimanD Variakojis
Feb 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J Ratain, Janet D Rowley
Jun 1, 1988·Investigational New Drugs·K V ShepardB Levin
Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hagop KantarjianE J Freireich
Jul 1, 1984·Cancer Genetics and Cytogenetics·D C Arthur, Clara D Bloomfield
Feb 9, 1995·The New England Journal of Medicine·A S Lichter, T S Lawrence
Sep 23, 1993·The New England Journal of Medicine·Michael J ThirmanA A Sandberg
Mar 1, 1996·British Journal of Haematology·Y ZhangBrigitte Schlegelberger
Apr 1, 1996·Hematology/oncology Clinics of North America·Michael J Thirman, Richard A Larson
Mar 10, 1999·Leukemia Research·G Lambertenghi DeliliersL Romitti
May 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debra M LillingtonA Z Rohatiner
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·J M AllanG J Morgan
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yanming ZhangJanet D Rowley

Citations

Nov 23, 2013·Breast Cancer Research and Treatment·Henry G KaplanGregory S Calip
Sep 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Yan MaHaiying Zen
Jul 20, 2007·Current Treatment Options in Oncology·Naomi GaliliAzra Raza
Apr 29, 2010·Current Hematologic Malignancy Reports·Brian T Hill, Edward A Copelan
Dec 8, 2010·Current Hematologic Malignancy Reports·Fabio P S SantosFarhad Ravandi
Apr 9, 2013·Current Hematologic Malignancy Reports·Karen-Sue B Carlson, Monica L Guzman
Feb 9, 2010·Medical Oncology·Ozgur KaraKadri Altundag
Oct 21, 2004·Best Practice & Research. Clinical Haematology·Steven D Gore
May 3, 2005·Leukemia Research·M TsurusawaMDS committee of the Japanese Society of Pediatric Hematology
Jun 2, 2005·Leukemia Research·Massimo BrecciaGiuliana Alimena
Apr 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Frank GriesingerD Haase
Aug 26, 2003·Best Practice & Research. Clinical Haematology·Martin S Tallman, Jacob M Rowe
Nov 1, 2003·Best Practice & Research. Clinical Haematology·Francesco Lo-CocoWilson H Miller
Feb 16, 2010·Bone Marrow Transplantation·Philippe ArmandRobert J Soiffer
Apr 17, 2009·Leukemia·Zhijian QianMichelle M Le Beau
Nov 15, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yi ZhouSa A Wang
Jan 18, 2008·Leukemia·Jens Pedersen-BjergaardDebes H Christiansen
Apr 15, 2005·The New England Journal of Medicine·Anita R MistryDavid Grimwade
Oct 29, 2004·The New England Journal of Medicine·Robert A Kyle, S Vincent Rajkumar
May 10, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R ShivakumarM Wetzler
Aug 2, 2012·Anti-cancer Drugs·Sanjay DixitMohan Hingorani
Sep 16, 2011·Current Opinion in Oncology·Giuseppe LeoneM T Voso
Jan 22, 2011·Current Opinion in Hematology·Ravi Bhatia, H Joachim Deeg
Sep 9, 2008·Journal of Pediatric Hematology/oncology·Tadashi MatsubayashiJun Miyahara
Apr 27, 2010·Journal of Pediatric Hematology/oncology·Hee-Won MoonMark Hong Lee
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H T SeeJ Kavanagh
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S YeasminK Miyazaki
Oct 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Smita Bhatia
Nov 21, 2007·Hematology·Jens Pedersen-BjergaardMette K Andersen
Nov 21, 2007·Hematology·Richard A Larson
Apr 23, 2009·Blood·Richard M Stone
Jan 13, 2010·Blood·Jianghong WangZhijian Qian
Aug 3, 2012·Journal of Hematology & Oncology·Luana FianchiM T Voso
Sep 23, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramon V TiuJaroslaw P Maciejewski
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sigurdur Y KristinssonLynn R Goldin
Mar 16, 2013·Polish journal of radiology·Anna Kwiatkowska-PamułaTomasz Adamczyk
May 19, 2005·American Journal of Clinical Pathology·C Cameron YinL Jeffrey Medeiros
Jan 14, 2005·International Journal of Hematology·Hiroyuki Mano
May 20, 2009·Future Oncology·Cortney V Jones, Edward A Copelan
Aug 24, 2011·Srpski arhiv za celokupno lekarstvo·Nebojsa AntonijevićM Colović
Nov 21, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Heath D Worcester, Mohammad A Vasef
Mar 13, 2009·Haematologica·Nicolaus KrögerMyelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of European Group for Blood and Marrow Transpl
Apr 2, 2009·Haematologica·Richard A Larson
Oct 14, 2011·Haematologica·T SchroederU Germing
Aug 2, 2012·International Journal of Environmental Research and Public Health·Reuben ThomasLuoping Zhang
Apr 15, 2014·Leukemia·L M MortonE A Engels
Feb 11, 2014·Best Practice & Research. Clinical Haematology·Jane E Churpek, Richard A Larson
Sep 23, 2014·Current Hematologic Malignancy Reports·Tomoko HataYasushi Miyazaki
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·S VanajakshiK Kshitija
Dec 5, 2009·Advances in Hematology·David M MintzerLauren Chmielewski
Nov 7, 2008·Wiener klinische Wochenschrift·R StauderP Valent
Mar 31, 2012·Neuro-oncology·Joachim M Baehring, Peter W Marks
Feb 14, 2006·Der Internist·W Pönisch, Dietger Niederwieser
Feb 28, 2007·Leukemia & Lymphoma·Jonathan E Kolitz
Jan 31, 2008·Leukemia & Lymphoma·Vicent Guillem, Mar Tormo
Nov 26, 2010·Expert Review of Hematology·Karen Yee, Armand Keating
Jan 9, 2015·International Journal of Molecular Sciences·Ting ZhouVivienne I Rebel
Mar 27, 2012·Expert Opinion on Biological Therapy·Massimo MartinoFortunato Morabito
Feb 14, 2015·Expert Opinion on Drug Safety·Myrna Candelaria, Alfonso Dueñas-Gonzalez
Jan 19, 2016·Current Opinion in Hematology·Virginia M Klimek, Nancy J Tray
Jun 22, 2013·Leukemia Research·Joshua Lukenbill, Matt Kalaycio
Mar 5, 2016·Frontiers in Oncology·Paul A Locke, Michael M Weil
Jun 14, 2015·American Journal of Clinical Pathology·Guilin TangL Jeffrey Medeiros
Jul 18, 2015·American Journal of Clinical Pathology·Carlos Bueso-RamosCurtis A Hanson
Dec 14, 2011·Human Pathology·Sa A Wang, Robert P Hasserjian
Dec 1, 2011·Best Practice & Research. Clinical Haematology·Eric J Feldman
Oct 11, 2015·Cancer Causes & Control : CCC·Adetokunbo OluwasanjoOlatunji Alese
Nov 29, 2011·Clinics in Laboratory Medicine·Olatoyosi OdenikeMichelle M Le Beau
Jul 14, 2010·Cancer Genetics and Cytogenetics·Angèle HerryMarc De Braekeleer
Apr 3, 2010·Hematology/oncology Clinics of North America·M A Sekeres
Dec 5, 2009·Chemico-biological Interactions·Zhijian QianMichelle M Le Beau
Dec 5, 2009·Seminars in Radiation Oncology·Andrea K NgLois B Travis
Sep 1, 2009·Clinical Lymphoma & Myeloma·Deepthi ManiDavid M Aboulafia
Jul 7, 2009·Hematology/oncology Clinics of North America·Phuong Nguyen
Jan 28, 2006·Mayo Clinic Proceedings·David P Steensma, John M Bennett
Jan 11, 2007·American Journal of Clinical Pathology·Zeba N SinghJames W Vardiman
Aug 12, 2008·Seminars in Oncology·Lucy A Godley, Richard A Larson
Jan 9, 2008·Seminars in Hematology·Charlotte Marie Niemeyer, Irith Baumann
Mar 6, 2007·Best Practice & Research. Clinical Haematology·Richard A Larson
Dec 13, 2006·Leukemia Research·Harold J Olney, Michelle M Le Beau
Nov 28, 2006·Lancet·Elihu H Estey, H Döhner
Jun 2, 2005·American Journal of Hematology·Toshie OgasawaraKiyotaka Kawauchi
Apr 25, 2009·British Journal of Haematology·Véronique Gelsi-BoyerDaniel Birnbaum
Jan 26, 2007·Pediatric Blood & Cancer·Uri TaboriDavid Malkin
Mar 30, 2007·European Journal of Haematology·Angèle HerryMarc De Braekeleer
May 17, 2007·American Journal of Hematology·Ethan A Natelson
Jun 2, 2007·British Journal of Haematology·Claire Seedhouse, Nigel Russell
Mar 8, 2008·British Journal of Haematology·Jorg BaseckeFrank Griesinger
Feb 28, 2008·British Journal of Haematology·Charlotte Marie Niemeyer, Christian Peter Kratz
Jun 16, 2010·European Journal of Haematology·Naoya MimuraKyoya Kumagai
Dec 20, 2011·American Journal of Hematology·Elihu H Estey
Nov 3, 2010·British Journal of Pharmacology·H SillA Wölfler
May 21, 2013·Genes, Chromosomes & Cancer·Dolors CostaSpanish Group of Myelodysplastic Syndromes (GESMD)
Mar 23, 2011·European Journal of Haematology·Aaron M CarlsonMark R Litzow
Jun 17, 2014·British Journal of Haematology·Megan E McNerneyK P White
Mar 13, 2014·Annals of the New York Academy of Sciences·Richard D Irons, Patrick J Kerzic
Jun 7, 2005·Chemico-biological Interactions·Richard A Larson, Michelle M Le Beau
Sep 4, 2004·Experimental Hematology·Chizuko TsutsumiHiroyuki Mano
Jun 26, 2004·Pathologie-biologie·Christine ChomienneFrench PV and ET Study Groups
Aug 9, 2006·DNA Repair·Yanming Zhang, Janet D Rowley
Jan 18, 2006·Annals of Diagnostic Pathology·Sergej Konoplev, Carlos Bueso-Ramos
Jun 15, 2011·Hematology·Nikesh Kawankar, Babu Rao Vundinti
Sep 27, 2005·Leukemia Research·Richard D IronsHua Fu
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Philippe ArmandRobert J Soiffer
Sep 25, 2015·Nature Communications·Chang-Lung LeeDavid G Kirsch
Apr 9, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rashmi S GoswamiGuilin Tang
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Simon B ZeichnerRobert John Poppiti
Mar 31, 2015·Environmental and Molecular Mutagenesis·Zhiying JiLuoping Zhang
May 31, 2014·Clinical Lymphoma, Myeloma & Leukemia·Alfonso Quintás-CardamaGuillermo Garcia-Manero
Jul 6, 2015·Current Treatment Options in Oncology·Simon B Zeichner, Martha L Arellano
Mar 10, 2012·The Korean Journal of Internal Medicine·Hye Jeong ParkWoong-Soo Lee
Jul 29, 2015·The Urologic Clinics of North America·Gino In, Tanya Dorff
Apr 16, 2016·Future Oncology·Vijaya R BhattJames O Armitage
Aug 12, 2014·Clinical Lymphoma, Myeloma & Leukemia·Ali Al-AmeriMohamad Cherry
Mar 3, 2015·Bone Marrow Transplantation·Ibrahim AldossVinod Pullarkat
Apr 16, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mehdi HamadaniEdward A Copelan
Jan 8, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ulrike BacherTorsten Haferlach
Dec 21, 2004·Cancer Cell·Richard A Van Etten, Kevin Shannon
Oct 4, 2012·Leukemia Research·Ibrahim Aldoss, Vinod Pullarkat
Sep 4, 2012·Leukemia Research·James W Vardiman
Feb 7, 2013·Leukemia Research·Massimo Breccia, Giuliana Alimena
Jan 24, 2015·International Journal of Clinical Pharmacy·Hayretdin KokluRamazan Civelek
Oct 18, 2005·Cancer Cell·Richard C ChaoKevin Shannon
Oct 3, 2013·Blood Research·Sang Hyuk ParkChan-Jeoung Park
Jul 7, 2010·The Korean journal of laboratory medicine·Jinhee ChoHong Ghi Lee
Mar 14, 2013·Annals of Laboratory Medicine·Hee Jae HuhHee-Jin Kim
Nov 30, 2010·Clinical Journal of Oncology Nursing·Deborah Kirk Walker, Jeanne Held-Warmkessel
Dec 4, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Andreas PeyrlPablo Hernáiz Driever
Apr 29, 2016·American Journal of Clinical Pathology·Elizabeth L CourvilleMichelle Dolan
Jul 15, 2016·Leukemia Research·Judith A MalmgrenHenry G Kaplan
Sep 8, 2016·Clinical Lymphoma, Myeloma & Leukemia·Koji SasakiFarhad Ravandi
Nov 30, 2016·British Journal of Cancer·Henrik FrederiksenHenrik T Sørensen
May 16, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Valentina NardiRobert P Hasserjian
May 16, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard A Larson
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dimitrios ChristoulasChristos A Papadimitriou
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonInternational Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards
Aug 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Myron S CzuczmanArturo Molina
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang KernC Schoch
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xavier LeleuSteven P Treon
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lene Sofie Granfeldt ØstgårdJan Maxwell Nørgaard
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matt KalaycioBrian Bolwell
Jan 19, 2017·Current Opinion in Hematology·S BlumM Lübbert
Aug 19, 2009·American Journal of Clinical Pathology·Magdalena Czader, Attilio Orazi
Feb 14, 2018·Blood·Franco Locatelli, Brigitte Strahm
Sep 14, 2017·Journal of Pediatric Hematology/oncology·Sarah B WhittleAndras Heczey
Nov 22, 2005·Bone Marrow Transplantation·Nicolaus KrögerMyelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of the European Group for Blood and Marrow Tra
Sep 14, 2016·World Journal of Stem Cells·Mohammad Faizan ZahidShahrukh K Hashmi
Aug 26, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Varinder KaurYogesh Jethava
Jul 9, 2004·Cancer·Stefan Faderl, Hagop Kantarjian
Jun 6, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Yi-Chun LinHsiao-Yi Lin
Sep 11, 2009·Melanoma Research·Carletta M CollinsJeffrey Sosman
Nov 16, 2004·Bone Marrow Transplantation·A FassasB Barlogie
Jan 19, 2007·Leukemia·J E LancetL C Moscinski
Feb 24, 2005·Current Opinion in Oncology·Jean-Luc Harousseau
Jul 22, 2014·Oncogene·D J VoceBakhtiar Yamini
Aug 25, 2017·Nature Reviews. Cancer·Megan E McNerneyMichelle M Le Beau
May 17, 2019·Journal of Cutaneous Pathology·Graziana GalloAnna Maria Cesinaro
Jan 4, 2018·Blood Advances·Koichi TakahashiP Andrew Futreal
Nov 24, 2005·Hematology·André Tichelli, Gérard Socié
Mar 24, 2006·Blood·Hartmut GeigerBrian D Weiss
Jul 10, 2019·Leukemia & Lymphoma·Justin D KanerAmit K Verma
Dec 28, 2019·Pediatric Transplantation·Deepak Chellapandian, Cameron L Nicholson
Feb 29, 2008·The Oncologist·Marshall A Lichtman
Mar 4, 2020·Current Hematologic Malignancy Reports·Nathalie Danielson, Michael Byrne
Dec 30, 2016·Oncotarget·Naoko HosonoJaroslaw P Maciejewski
Dec 22, 2017·British Journal of Haematology·Makiko HoraiYasushi Miyazaki
Oct 14, 2014·Expert Review of Clinical Immunology·Stavroula Giannouli, Michael Voulgarelis
Oct 29, 2014·Expert Review of Hematology·Nicolas DuployezClaude Preudhomme
Jan 27, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Antonio GidaroRoberto Castelli
Feb 6, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mohamed Abd El-Fattah
Apr 29, 2009·Radiation Research·Assumpta DuranLeonardo Barrios
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher J GibsonBenjamin L Ebert
Jul 1, 2013·Frontline Gastroenterology·Omer F AhmadStuart L Bloom
Apr 21, 2018·Blood·Koichi Takahashi
Apr 22, 2015·World Journal of Gastroenterology : WJG·Ying-Cheng ZhangYong-Jin Li
Jan 1, 2015·Molecular & Cellular Oncology·Adam M Schmitt, Bakhtiar Yamini
Jul 31, 2020·Medicina·Yuliya Andreevna VeryaskinaIgor Fyodorovich Zhimulev
May 23, 2016·Mutagenesis·Leena RivinaRobert H Schiestl
Dec 5, 2017·Journal of Pediatric Hematology/oncology·Kyung Taek HongHee Young Shin
Sep 12, 2018·Annals of Hematology·Helena ClaerhoutNancy Boeckx
Mar 2, 2019·British Journal of Haematology·Nicolaus KrögerChronic Malignancies Working Party of the European Society for Blood Marrow Transplantation
Jan 23, 2019·Annals of Hematology·Edna CheungBernard L Marini
Jan 17, 2017·Blood Research·Hee Won ChoKeon Hee Yoo
Aug 3, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yang LiEndi Wang
Jul 10, 2020·Genes·Alexandra Higgins, Mithun Vinod Shah
Apr 29, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher J Gibson, David P Steensma
Jan 5, 2021·Cancer Causes & Control : CCC·Rina YaroshJenny N Poynter
Mar 7, 2020·Best Practice & Research. Clinical Haematology·Kylee MaclachlanDickran Kazandjian

Related Concepts

Teens
Adult
Elderly (population group)
Nonagenarians
Child
Child, Preschool
Autosome Abnormalities
Females
Homo sapiens
Leukemia, Monocytic, Chronic

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.