Clinical decision making in the emergency department setting using rapid PCR: Results of the CLADE study group

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Glen T HansenMarcia Deike

Abstract

Emergency Departments (ED) are challenged during influenza season by patients who present acutely during sporadic ED visits. ED management is largely empiric, often occurring without reliable diagnostics needed for targeted therapies, safe outpatient discharge, or hospital admissions. To evaluate the impact of the influenza diagnosis on physician decision making during ED visits using the Cobas Liat® influenza A + B assay. Prospective study assessing the impact of rapid (<30 min), reverse-transcriptase polymerase chain reaction (RT-PCR) influenza testing on physician decision making in the ED. Physician responses established pre-and post-diagnosis management courses which required confirmation via secondary documentation in the medical record. Changes in physician decision making were analyzed across four clinical touchpoints: (i) admission/discharge status, (ii) medical procedures, (iii) antiviral and antibiotic prescribing, and (iv) laboratory studies. An influenza diagnosis changed patient management courses, relative to empiric, pre-diagnosis plans, in in 61% of the cases resulting in cost savings of $49,420-to-$42,270 over 143 patients and 104 days during influenza season resulting in a cost savings of $200.40/ED visit. Ev...Continue Reading

Citations

Jan 4, 2019·Journal of Clinical Microbiology·Robert C BenirschkeSanchita Das
May 31, 2019·Journal of Clinical Microbiology·B A Pinsky, R T Hayden
Mar 17, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jan Y VerbakelChristopher C Butler
Jan 13, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yogesh SharmaCampbell Thompson
Aug 24, 2020·The Journal of Pediatrics·Rana E El FeghalyRangaraj Selvarangan
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Feb 19, 2021·Journal of Clinical Microbiology·Linoj P SamuelUNKNOWN ASM Clinical and Public Health Microbiology Committee
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Methods Mentioned

BETA
PCR

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