Clinical Decision Support and Palivizumab: A Means to Protect from Respiratory Syncytial Virus

Applied Clinical Informatics
L H UtidjianR W Grundmeier

Abstract

Palivizumab can reduce hospitalizations due to respiratory syncytial virus (RSV), but many eligible infants fail to receive the full 5-dose series. The efficacy of clinical decision support (CDS) in fostering palivizumab receipt has not been studied. We sought a comprehensive solution for identifying eligible patients and addressing barriers to palivizumab administration. We developed workflow and CDS tools targeting patient identification and palivizumab administration. We randomized 10 practices to receive palivizumab-focused CDS and 10 to receive comprehensive CDS for premature infants in a 3-year longitudinal cluster-randomized trial with 2 baseline and 1 intervention RSV seasons. There were 356 children eligible to receive palivizumab, with 194 in the palivizumab-focused group and 162 in the comprehensive CDS group. The proportion of doses administered to children in the palivizumab-focused intervention group increased from 68.4% and 65.5% in the two baseline seasons to 84.7% in the intervention season. In the comprehensive intervention group, proportions of doses administered declined during the baseline seasons (from 71.9% to 62.4%) with partial recovery to 67.9% during the intervention season. The palivizumab-focused gr...Continue Reading

References

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May 15, 2003·Pediatric Pulmonology·Curt ParnesUNKNOWN Palivizumab Outcomes Registry Study Group
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Feb 7, 2009·The New England Journal of Medicine·Caroline Breese HallPeter Szilagyi
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Jul 30, 2014·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Infectious Diseases, UNKNOWN American Academy of Pediatrics Bronchiolitis Guidelines Committee

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Citations

Feb 7, 2018·Journal of Medical Internet Research·Clemens Scott Kruse, Amanda Beane
May 8, 2019·Paediatric Respiratory Reviews·Manuel Sánchez LunaXavier Carbonell-Estrany
May 19, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jeremy J MichelRichard M Rosenfeld

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