Clinical demographics of multiplex families with multiple sclerosis. Multiple Sclerosis Genetics Group

Annals of Neurology

Abstract

The demographic and clinical characteristics of 89 multiplex families whose affected members meet proposed diagnostic criteria for multiple sclerosis (MS) genetic research are described and compared with 425 sporadic cases of MS and other published collections of MS multiplex families. The proportion of affected multiplex family members who experienced gradual progression of disability from onset (primary progressive MS) is lower than reported by other investigators. Different phenotypes of MS may reflect genetic heterogeneity that may partially explain inconsistencies in the results of genetic linkage studies. Clinical details of affected multiplex family members must be described so that comparisons of genetic results across studies can be properly interpreted.

References

Sep 1, 1990·Neurology·B G WeinshenkerG C Ebers
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·O OlerupJ Wallin
Jul 1, 1988·Acta Neurologica Scandinavica·T Engell
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
May 1, 1995·Journal of Neuroimmunology·H F Kellar-WoodD A Compston
Jan 15, 1994·American Journal of Medical Genetics·M R Natowicz, B Bejjani
Aug 1, 1996·Neurology·N P RobertsonD A Compston
Jul 1, 1996·Brain Pathology·J R OksenbergS L Hauser
Jun 1, 1997·Brain : a Journal of Neurology·A J ThompsonJ De Sá
Jun 1, 1997·Medizinische Monatsschrift für Pharmazeuten·M Offenhäusser, R Martin
Jun 1, 1963·Brain : a Journal of Neurology·K SCHAPIRAH MILLER

❮ Previous
Next ❯

Citations

Mar 18, 2005·Journal of Neurology·Małgorzata Siger-Zajdel, Krzysztof W Selmaj
Apr 9, 2002·Current Neurology and Neuroscience Reports·Rhonda R Voskuhl
Jan 10, 2001·Inflammatory Bowel Diseases·M PeetersJ F Colombel
Dec 17, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L Romero-PinelT Arbizu
Mar 7, 2002·Journal of Neuroimmunology·Orhun H KantarciBrian G Weinshenker
Jan 22, 2005·Neurologic Clinics·Jorge R Oksenberg, Stephen L Hauser
Jan 31, 2003·American Journal of Human Genetics·L F BarcellosUNKNOWN Multiple Sclerosis Genetics Group
Feb 16, 2008·Proteome Science·Cornelius J WernerSabine Wolf
Oct 4, 2006·Annual Review of Pharmacology and Toxicology·Michael P Murphy, Robin A J Smith
Sep 11, 2001·Multiple Sclerosis : Clinical and Laboratory Research·A J GreenS L Hauser
Sep 26, 2012·Nature Reviews. Neurology·Hans LassmannDon Mahad
Jun 28, 2000·Current Opinion in Neurology·C J Willer, G C Ebers
Feb 9, 2002·Brain : a Journal of Neurology·L F BarcellosUNKNOWN Multiple Sclerosis Genetics Group
Feb 1, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V M AlifirovaYa S Gumenyuk
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·D S Goodin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Multiple Sclerosis : Clinical and Laboratory Research
C ConfavreuxT Moreau
Multiple Sclerosis : Clinical and Laboratory Research
Marcus KochJacques De Keyser
© 2022 Meta ULC. All rights reserved