Clinical determinants of fever in clozapine users and implications for treatment management: A narrative review

Schizophrenia Research
Hélène VerdouxJose de Leon

Abstract

To identify the clinical determinants of fever in clozapine users and their impact on management of clozapine treatment. Articles published in English or French identified with a MEDLINE, Web of Sciences, Cochrane Library and PsycINFO search, from inception through February 2019, using the term "clozapine" in combination with "fever" OR "hyperthermia" OR "body temperature" OR "pyrexia" OR "febrile" OR "heat" OR "thermoregulation". Information extracted for each medical condition were frequency, time to onset after initiation of clozapine treatment, characteristics of fever, associated symptoms, laboratory tests used for diagnosis, course, lethality, discontinuation of clozapine. Data were synthesized narratively. Our search yielded 394 unique hits published from 1993 to 2018. We included 73 articles in the review: two meta-analyses, 14 reviews, six epidemiological studies, 11 clinical studies and 40 case reports. During clozapine initiation, fever is most frequently benign and transient but should be closely monitored as it may be the first stage of potentially life-threatening adverse drug reactions (ADR) (agranulocytosis, neuroleptic malignant syndrome myocarditis, hepatitis, pancreatitis, nephritis, colitis, etc.). Other ADR...Continue Reading

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Citations

Mar 3, 2020·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Jose de LeonCan-Jun Ruan
Apr 26, 2020·Journal of Clinical Psychopharmacology·Georgios SchoretsanitisJose de Leon
Apr 9, 2020·Acta Psychiatrica Scandinavica·H Verdoux, C Quiles
Sep 21, 2020·Neuropsychopharmacology Reports·Kota KikuchiKazutaka Shimoda
May 19, 2020·General Psychiatry·Jose de LeonChuanyue Wang
Jan 20, 2021·Expert Review of Clinical Pharmacology·Georgios SchoretsanitisJose de Leon
Feb 16, 2021·Journal of Clinical Psychopharmacology·Georgios SchoretsanitisJose de Leon
May 22, 2021·Pharmacological Reviews·Samantha Christine SernoskieJack Paul Uetrecht
Aug 9, 2021·Schizophrenia Research·Renato de FilippisGeorgios Schoretsanitis
Apr 15, 2020·Psychotherapy and Psychosomatics·Jose de LeonCarlos De Las Cuevas

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