Abstract
Patients with fulminant myocarditis (FM) often present with cardiogenic shock and require mechanical circulatory support, including extracorporeal membrane oxygenation (ECMO) and ventricular assist device (VAD) implantation. This study sought to clarify the determinants of successful weaning from ECMO in FM patients. We studied 37 consecutive FM patients supported by ECMO as the initial form of mechanical circulatory support between January 1995 and December 2014 in our hospital. Twenty-two (59%) patients were successfully weaned from ECMO, while 15 (41%) were not. There were significant differences in levels of peak creatine kinase and those of its MB isoform (CK-MB), left ventricular posterior wall thickness (LVPWT), and prevalence of cardiac rhythm disturbances. Receiver operating characteristic curve analysis revealed that a peak CK-MB level of 185 IU/L and LVPWT of 11 mm were the optimal cut-off values for predicting successful weaning from ECMO (areas under the curve, 0.89 and 0.85, respectively). During the follow-up [median 48 (interquartile range 8-147) months], 83% of FM patients who were weaned from ECMO survived, with preserved fractional shortening based on echocardiography. Of the 15 FM patients who were not weane...Continue Reading
References
Jun 1, 1987·Human Pathology·H T Aretz
Jan 1, 1994·Circulation·N A DruckerJ W Newburger
Mar 9, 2000·The New England Journal of Medicine·R E McCarthyK L Baughman
Mar 27, 2001·The Annals of Thoracic Surgery·M A Acker
Mar 27, 2001·Japanese Circulation Journal·T AibaT Nakatani
Sep 15, 2004·Journal of the American College of Cardiology·Mototsugu NishiiTohru Izumi
Jan 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yih-Sharng ChenWen-Je Ko
Jul 15, 2005·European Heart Journal·Yasuhide AsaumiShunichi Miyazaki
Nov 28, 2007·Annual Review of Pathology·Mitra Esfandiarei, Bruce M McManus
Aug 30, 2008·Surgery Today·Akira SezaiKazutomo Minami
Sep 18, 2008·Nature Clinical Practice. Cardiovascular Medicine·Sachin GuptaPradeep Pa Mammen
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Olivier N PagesPascal Leprince
Mar 31, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shunsuke SaitoYoshiki Sawa
Jul 14, 2010·Circulation·Donna Mancini, Katherine Lietz
Nov 30, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Daisuke YoshiokaYoshiki Sawa
May 9, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pavan AtluriY Joseph Woo
Oct 3, 2013·Circulation·Marco AnziniGianfranco Sinagra
Dec 18, 2013·The American Journal of Cardiology·Christina Y MiyakeDouglas Y Mah
Mar 20, 2014·Journal of Cardiac Failure·Richard ChengBabak Azarbal
Oct 17, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi NakataniMitsuaki Isobe
Mar 5, 2015·Critical Care Medicine·J Wesley DiddleRavi R Thiagarajan
Apr 12, 2015·Journal of the American College of Cardiology·Charanjit S RihalUNKNOWN Society for Cardiovascular Angiography and Interventions (SCAI), Heart Failure Society of America (HFSA), Society of Thoraci
Jun 3, 2015·European Heart Journal·Matthieu SchmidtDavid Pilcher
Nov 1, 2015·The Annals of Thoracic Surgery·Roberto LorussoUNKNOWN GIROC Investigators
Apr 1, 2016·Critical Care Medicine·Giulio CavalliMoreno Tresoldi
Citations
May 3, 2019·Expert Review of Medical Devices·Yuichiro KadoJamshid H Karimov
Nov 14, 2019·Circulation. Heart Failure·Abdulrahman A Al-FaresEddy Fan
Sep 5, 2020·The European Respiratory Journal·Trevor J Williams, Vincent Pellegrino
Feb 23, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Satsuki FukushimaTomoyuki Fujita
May 24, 2020·Cardiovascular Drugs and Therapy·Satsuki FukushimaTomoyuki Fujita
Jul 30, 2019·Case Reports in Emergency Medicine·Saki Hasegawa-TambaShintaro Nakano
May 1, 2021·Journal of Clinical Medicine·Yun Im LeeYang Hyun Cho
May 29, 2021·Microvascular Research·Xiaohong ZhangJun Li
Jun 27, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Naoki TadokoroTomoyuki Fujita
Mar 18, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Shingo OhkiNobuaki Shime
Jul 13, 2021·Circulation. Heart Failure·Darshan H BrahmbhattFilio Billia
Sep 4, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·John M TrahanasDavid A D'Alessandro
Feb 6, 2020·Recent Patents on Inflammation & Allergy Drug Discovery·Ronald C M FungAlexander K C Leung
Nov 23, 2021·The Journal of International Medical Research·Heyu MengPing Yang