Clinical development and potential of photothermal and photodynamic therapies for cancer.

Nature Reviews. Clinical Oncology
Xingshu LiXiaoyuan Chen

Abstract

Light-activated, photosensitizer-based therapies have been established as safe modalities of tumour ablation for numerous cancer indications. Two main approaches are available: photodynamic therapy, which results in localized chemical damage in the target lesions, and photothermal therapy, which results in localized thermal damage. Whereas the administration of photosensitizers is a key component of photodynamic therapy, exogenous photothermal contrast agents are not required for photothermal therapy but can enhance the efficiency and efficacy of treatment. Over the past decades, great strides have been made in the development of phototherapeutic drugs and devices as cancer treatments, but key challenges have restricted their widespread clinical use outside of certain dermatological indications. Improvements in the tumour specificity of photosensitizers, achieved through targeting or localized activation, could provide better outcomes with fewer adverse effects, as could combinations with chemotherapies or immunotherapies. In this Review, we provide an overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challeng...Continue Reading

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Citations

Nov 28, 2020·Chemical Society Reviews·Cheng Xu, Kanyi Pu
Jan 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Andris F Bakuzis
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Methods Mentioned

BETA
light scattering
surgical resection
fluorescence-guided resection
biopsy
X-ray

Clinical Trials Mentioned

NCT02872064
NCT02939274
NCT03033225
NCT02702700
NCT02448381
NCT03945162
NCT00807924
NCT00848042
NCT04240639

Software Mentioned

Neuroblate
Visualase

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