Clinical development of trastuzumab in breast cancer

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Y TokudaT Tajima

Abstract

The HER-2/neu protein is thought to be a unique and useful target for antibody therapy of cancers overexpressing the HER-2/neu gene. The recombinant humanized anti-HER-2 monoclonal antibody, trastuzumab (Herceptin) is now available for clinical use in the U.S.A. It is also expected to be available in Japan in the near future. In this paper, the details of this novel biologic agent are reviewed in conjunction with a phase I study performed in Japan.

References

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Citations

Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Alexandra GiatromanolakiVassilis Georgoulias
Dec 25, 2003·The Proceedings of the Nutrition Society·John C Mathers
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M P PiechockiW Z Wei
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valéry RenardDana R Leach

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