PMID: 8608479Mar 1, 1996Paper

Clinical diagnosis and therapy of cutaneous melanoma in situ

Cancer
Cesare BartoliN Cascinelli

Abstract

The frequency of in situ melanoma is increasing, and it is often diagnosed fortuitously by histology. We retrospectively reviewed 121 melanomas in situ in 113 patients with the aim of identifying the clinical features of, and optimal surgical treatment for this cutaneous malignancy. Treatment was limited surgery with 3 mm margins of excision in 69 cases (57%) and wider margins of excision (more than 3 mm) in 52 cases (43%). The lesions had a median diameter of 1 cm (range, 2-35 mm) and were generally macular (92% of cases) asymmetric (87%), with an irregular border (88%) and nonuniform pigmentation (98%), usually in shades of brown (41%) and black (48%). These features had permitted a clinical diagnosis of melanoma or suspected melanoma in 62% of cases and of doubtful nevus in an additional 18% of cases. At a median follow-up of 4 years, there were six local recurrences (three treated by limited surgery and three by wider excision), all in situ melanomas. The typical clinical features of melanoma in situ, which are similar to those of early invasive melanoma, are usually sufficiently distinctive to suggest the clinical diagnosis of melanoma or suspected melanoma. Except for large size and superficially extended lesions (larger ...Continue Reading

References

Nov 1, 1992·Journal of the American Academy of Dermatology·H M Shaw, W H McCarthy
Sep 9, 1992·JAMA : the Journal of the American Medical Association
Sep 16, 1992·Journal of the National Cancer Institute·R MacLennanN G Martin
Jul 1, 1990·Journal of Surgical Oncology·C M Balch
Mar 1, 1984·Przegla̧d dermatologiczny·Z Samochocki
Apr 1, 1984·The American Journal of Dermatopathology·F PiscioliM Cristofolini
Jan 1, 1981·Journal of Surgical Oncology·E C KrishnanW R Jewell
Aug 1, 1983·The Journal of Dermatologic Surgery and Oncology·A B Ackerman
Jun 1, 1982·The Journal of Dermatologic Surgery and Oncology·D J GrandeD C Whitaker
Jul 15, 1994·Cancer·M M Urist, L H Karnell
Oct 1, 1993·Journal of the American Academy of Dermatology·G C RoushR L Barnhill

❮ Previous
Next ❯

Citations

Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·R M KedlS Dow
Jun 3, 2011·The Oncologist·Simone Mocellin, Donato Nitti
Nov 17, 2009·Clinics in Plastic Surgery·Mark W BosbousMarcelle Neuburg
Jul 31, 2007·Dermatologic Clinics·Medhat A El-MoftyMona R E Abdel-Halim
Jul 18, 2015·Journal of the American Academy of Dermatology·H William HigginsDavid J Leffell
Mar 5, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·P RosinaG Girolomoni
Sep 16, 2014·Journal of the American Academy of Dermatology·Arianna WelchMorgan L Wilson
Feb 1, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alexander Maley, Arthur R Rhodes
Oct 12, 2001·Melanoma Research·A BonoC Bartoli
Jul 13, 2002·American Journal of Clinical Dermatology·Pearon G Lang
Jun 10, 2005·American Journal of Clinical Dermatology·Olivia Stevenson, Imtiaz Ahmed
Jul 8, 2020·Archives of Dermatological Research·Alexander M CartronAmor Khachemoune
Jun 29, 2018·Current Treatment Options in Oncology·Yoshiyuki Nakamura, Yasuhiro Fujisawa
Apr 29, 1998·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·D A HudsonR Grover

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.