Clinical diagnosis in Karwinskia humboldtiana polyneuropathy

Journal of the Neurological Sciences
H R MartínezL de Leon Flores

Abstract

Intoxication by Karwinskia humboldtiana presents a neurological picture similar to that for Guillain-Barré syndrome or other polyradiculoneuropathies. Clinical diagnosis in poisoned humans may be difficult if no evidence of previous fruit ingestion is available. We present our experience in the clinical diagnosis of Karwinskia humboldtiana polyneuropathy, as confirmed by toxin detection in blood. We designed an open trial at the Pediatric Neurology service and included all cases with acute ascending paralysis that were admitted to our hospital in the last two years. In all cases, we performed hematological, immunological and biochemical profiles, CSF analysis including immunological studies, oligoclonal bands and myelin basic protein determinations. Electrodiagnostic studies were performed, including motor conduction velocities, distal latencies, F-wave latency and compound muscle action potential (CAMP) amplitude. The presence of Karwinskia humboldtiana toxins in blood were determined by thin layer chromatography. In six cases, T-514 Karwinskia humboldtiana toxin was detected. These cases had a symmetric motor polyneuropathy with the absence of tendon reflexes and no sensory signs or cranial nerve involvement. Only one patient...Continue Reading

References

Aug 30, 1975·Journal of the American Chemical Society·D L DreyerG D Daves
Nov 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·M V BermúdezA Piñeyro
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·M V BermudezA Piñeyro
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·G Flores-OteroC Rubio-Franchini
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·M GuerreroN Waksman
Jan 1, 1972·Toxicon : Official Journal of the International Society on Toxinology·H L Kim, B J Camp
Jan 8, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·M H Wheeler, B J Camp
Nov 1, 1983·Journal of Neurobiology·K Aoki, E J Muñoz-Martínez
Mar 1, 1983·Neuropathology and Applied Neurobiology·E J Muñoz-MartínezP Joseph-Nathan
Oct 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·L Garza-OcañasA Piñeyro-Lopez

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Citations

Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·F Jaramillo-JuárezJ L Reyes
Jun 17, 2003·Journal of Toxicology. Clinical Toxicology·Julian WhiteGeoffrey K Isbister
May 25, 2010·Disease-a-month : DM·David P Randall
Aug 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·Eduardo M Becerra-VerdinJulio Sepúlveda-Saavedra
Aug 26, 2006·Journal of the Peripheral Nervous System : JPNS·Martha E Salazar-LealM V Bermudez
Jun 28, 2013·The Journal of General Virology·W Allan NixM Steven Oberste
Mar 24, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·L Valeria Ocampo-RoosensObed Fernández-Lucio
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gilberto Jaramillo-RangelMarta Ortega-Martínez

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