Clinical diagnosis of Lewy body dementia.

BJPsych Open
Ajenthan SurendranathanJ T O'Brien

Abstract

Lewy body dementia, consisting of both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is considerably under-recognised clinically compared with its frequency in autopsy series. This study investigated the clinical diagnostic pathways of patients with Lewy body dementia to assess if difficulties in diagnosis may be contributing to these differences. We reviewed the medical notes of 74 people with DLB and 72 with non-DLB dementia matched for age, gender and cognitive performance, together with 38 people with PDD and 35 with Parkinson's disease, matched for age and gender, from two geographically distinct UK regions. The cases of individuals with DLB took longer to reach a final diagnosis (1.2 v. 0.6 years, P = 0.017), underwent more scans (1.7 v. 1.2, P = 0.002) and had more alternative prior diagnoses (0.8 v. 0.4, P = 0.002), than the cases of those with non-DLB dementia. Individuals diagnosed in one region of the UK had significantly more core features (2.1 v. 1.5, P = 0.007) than those in the other region, and were less likely to have dopamine transporter imaging (P < 0.001). For patients with PDD, more than 1.4 years prior to receiving a dementia diagnosis: 46% (12 of 26) had documented impaired activ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 22, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·D AarslandJ P Larsen
Dec 11, 2002·Neurology·C G BallardM Tovee
Jul 26, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Dag AarslandCarol Brayne
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Jul 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M OinasA Paetau
Dec 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Bruno DuboisMurat Emre
Mar 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Mariese A HelyJohn G L Morris
Oct 31, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Rodney W H Walker, Zuzana Walker
May 4, 2010·Parkinsonism & Related Disorders·James E GalvinSteven H Zarit
Jul 30, 2010·The Gerontologist·Amanda N LeggettJames E Galvin
Jul 18, 2014·Alzheimer's Research & Therapy·Yael R Zweig, James E Galvin
Aug 31, 2014·Neurology·Julius B M AnangRonald B Postuma
Nov 29, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Zuzana WalkerUNKNOWN DaTSCAN DLB Phase 4 Study Group
Jan 15, 2016·International Journal of Geriatric Psychiatry·Ellen SvendsboeArvid Rongve
Jun 17, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·David B HoganNathalie Jetté
Oct 17, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Giovanni RizzoGiancarlo Logroscino
Feb 17, 2018·Alzheimer's Research & Therapy·Joseph P M KaneJohn T O'Brien
Mar 8, 2018·BMC Medicine·Kurt A Jellinger, Amos D Korczyn
Jun 10, 2019·Journal of Alzheimer's Disease : JAD·Marleen van de BeekWiesje M van der Flier

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Citations

Dec 3, 2020·Frontiers in Cell and Developmental Biology·Yu-Mi JeonHyung-Jun Kim
Feb 21, 2021·Alzheimer's Research & Therapy·A SurendranathanJ T O'Brien
Apr 2, 2021·BMC Neurology·Jinghuan GanUNKNOWN China Lewy Body Disease Collaborative Alliance
Jun 12, 2021·Journal of Geriatric Psychiatry and Neurology·Kathryn A Wyman-ChickMatthew J Barrett
Jun 20, 2021·Journal of Advanced Nursing·Allison BentleyCatherine Walshe
Nov 12, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Parichita ChoudhuryTanis J Ferman

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Methods Mentioned

BETA
MDS

Software Mentioned

Statistical Package for Social Sciences

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