Clinical diagnostic gene expression thyroid testing

Otolaryngologic Clinics of North America
David L Steward, Richard T Kloos

Abstract

Thyroid fine-needle aspiration biopsies are cytologically indeterminate in 15% to 30% of cases. When cytologically indeterminate thyroid nodules undergo diagnostic surgery, approximately three-quarters prove to be histologically benign. A negative predictive value of more than or equal to 94% for the Afirma Gene Expression Classifier (GEC) is achieved for indeterminate nodules. Most Afirma GEC benign nodules can be clinically observed, as suggested by the National Comprehensive Cancer Network Thyroid Carcinoma Guideline. More than half of the benign nodules with indeterminate cytology (Bethesda categories III/IV) can be identified as GEC benign and removed from the surgical pool to prevent unnecessary diagnostic surgery.

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Related Concepts

Parathyroid Diseases
Histology Procedure
Nodule
Genome
Cytological Techniques
Impacted Tooth
Test, Cytology, Digestive
Genetic Screening Method
Surgical Pathology Procedure
Neoplasms

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