Clinical Diagnostic Testing for Human Cytomegalovirus Infections.

The Journal of Infectious Diseases
Raymund R RazonableD Scott Schmid

Abstract

Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more congenital infections worldwide than any other agent. Congenital HCMV (cCMV) infections are the leading nongenetic cause of sensorineural hearing loss and a source of significant neurological disabilities in children. While there is overlap in the clinical and laboratory approaches to diagnosis of HCMV infections in these settings, the management, follow-up, treatment, and diagnostic strategies differ considerably. As yet, no country has implemented a universal screening program for cCMV. Here, we summarize the issues, limitations, and application of diagnostic strategies for transplant recipients and congenital infection, including examples of screening programs for congenital HCMV that have been implemented at several centers in Japan, Italy, and the United States.

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Citations

Nov 26, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Prince SinghRaymund R Razonable
Mar 27, 2021·American Journal of Obstetrics & Gynecology MFM·Lisa Hui, Antonia Shand
Jul 4, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Andrew H KarabaRobin K Avery
Jul 27, 2021·Current Treatment Options in Infectious Diseases·Niyati JakhariaDavid J Riedel
Sep 3, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle AtayaMiguel López-Botet

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