PMID: 11915378Mar 28, 2002Paper

Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

Nippon Ganka Gakkai zasshi
Mitsuko YuzawaMizuo Matsui

Abstract

To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

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