Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia

Neurology
G L LunardiE Favale

Abstract

This paper reports on the effectiveness of oral lamotrigine in 15 patients suffering from "essential" trigeminal neuralgia and in five patients suffering symptomatic trigeminal neuralgia concomitant with multiple sclerosis. We recorded objective and subjective pain ratings and correlated them to daily dosage (400 mg maximum) and plasma levels of the drug. We detected pain relief proportional to daily dosage and to drug plasma levels. Eleven of the cases affected by the "essential" form of neuralgia showed complete pain relief on reaching their maximum daily dosage. All cases affected by the symptomatic form had complete pain relief. We could detect no changes from these results by the end of the follow-up period (3 to 8 months after the study ended).

Citations

Jan 16, 2007·Journal of Neurology·David A BechtoldKenneth J Smith
Mar 20, 2002·Current Neurology and Neuroscience Reports·R T Schapiro
Dec 20, 2012·Current Neurology and Neuroscience Reports·Claudio SolaroMichele Messmer Uccelli
Jul 10, 2009·Current Pain and Headache Reports·Marcelo E Bigal
Nov 11, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L M MetzD McGowan
Aug 17, 2011·Nature Reviews. Neurology·Claudio Solaro, Michele Messmer Uccelli
Oct 23, 2002·Headache·Jose M Gutierrez-Garcia
Sep 17, 2002·Clinical Evidence·Joanna M Zakrzewska
Jul 23, 2003·International Anesthesiology Clinics·Neeraj KapurAndrew Herlich
Jun 6, 2007·Drugs·Elon EisenbergNorberto Krivoy
Nov 5, 2003·CNS Drugs·Gary McCleane
Mar 14, 2008·CNS Drugs·Walter Pöllmann, Wolfgang Feneberg
Jul 1, 2011·Pain Management·Joel J Napeñas, Joanna M Zakrzewska
Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Roberto De SimoneVincenzo Bonavita
Jun 11, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C SolaroG L Mancardi
Nov 9, 2005·Expert Review of Neurotherapeutics·Elon EisenbergNorberto Krivoy
Sep 16, 2011·Expert Opinion on Pharmacotherapy·Andrea TruiniGiorgio Cruccu
Mar 15, 2006·Expert Review of Neurotherapeutics·Sergio Canavero, Vincenzo Bonicalzi
Sep 1, 2003·Expert Review of Neurotherapeutics·Massimo Leandri
Sep 18, 2007·Expert Review of Neurotherapeutics·Claudio SolaroMichele Messmer Uccelli
May 28, 2004·Expert Opinion on Pharmacotherapy·Gary McCleane
Apr 30, 2010·Expert Opinion on Pharmacotherapy·Joanna M Zakrzewska
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Khizar MalikPhilippe D Vaillancourt
Dec 2, 2011·Clinical Neurology and Neurosurgery·Lorenzo De Santi, Pasquale Annunziata
Apr 2, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J M Gomez-ArguellesB Anciones
Jul 31, 2007·Journal of Pain and Symptom Management·Marianne SilverSteve Quessy
Oct 25, 2003·European Journal of Pain : EJP·Elon EisenbergNorberto Krivoy
Jun 6, 2006·Clinical Therapeutics·Heidi J Crayton, Howard S Rossman
Oct 26, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Steven J ScrivaniRaymond J Maciewicz
Apr 6, 2004·Neurologic Clinics·Todd D Rozen
Jul 13, 2004·Neurosurgery Clinics of North America·James K Liu, Ronald I Apfelbaum
Jan 18, 2006·Headache·Marina TitlicJelena Jukic
Feb 26, 2014·Current Opinion in Pharmacology·Ann G HayesSimon Tate
Jun 4, 2016·American Journal of Clinical Dermatology·Feras M Al-GhazawiJennifer Beecker
Sep 27, 2003·Arquivos de neuro-psiquiatria·Elcio Juliato PiovesanLineu Cesar Werneck
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·P F Smith, C L Darlington
Sep 19, 2001·Pharmacotherapy·D R Guay
Mar 13, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L BendtsenG Cruccu
Dec 4, 2013·The Cochrane Database of Systematic Reviews·Philip J WiffenR Andrew Moore
May 10, 2020·CNS Drugs·Giulia Di StefanoAndrea Truini
Aug 8, 2019·Current Pain and Headache Reports·Mark R JonesOmar Viswanath

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