Clinical Effectiveness of Prospectively Reported Sonographic Twinkling Artifact for the Diagnosis of Renal Calculus in Patients Without Known Urolithiasis

AJR. American Journal of Roentgenology
William R MaschMatthew S Davenport

Abstract

The purpose of this study was to determine the clinical effectiveness of prospectively reported sonographic twinkling artifact for the diagnosis of renal calculus in patients without known urolithiasis. All ultrasound reports finalized in one health system from June 15, 2011, to June 14, 2014, that contained the words "twinkle" or "twinkling" in reference to suspected renal calculus were identified. Patients with known urolithiasis or lack of a suitable reference standard (unenhanced abdominal CT with ≤ 2.5-mm slice thickness performed ≤ 30 days after ultrasound) were excluded. The sensitivity, specificity, and positive likelihood ratio of sonographic twinkling artifact for the diagnosis of renal calculus were calculated by renal unit and stratified by two additional diagnostic features for calcification (echogenic focus, posterior acoustic shadowing). Eighty-five patients formed the study population. Isolated sonographic twinkling artifact had sensitivity of 0.78 (82/105), specificity of 0.40 (26/65), and a positive likelihood ratio of 1.30 for the diagnosis of renal calculus. Specificity and positive likelihood ratio improved and sensitivity declined when the following additional diagnostic features were present: sonographic ...Continue Reading

References

Apr 1, 1996·Radiology·A RahmouniN Vasile
Oct 8, 1998·AJR. American Journal of Roentgenology·N ChelfouhP Ballanger
Sep 9, 1999·Journal of Clinical Ultrasound : JCU·S K Aytaç, H Ozcan
Dec 23, 2008·AJR. American Journal of Roentgenology·Hisham Tchelepi, Philip W Ralls
Apr 5, 2011·Radiology·Jonathan R DillmanRonald O Bude
Sep 27, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ania Z KielarJonathan Rubin
Oct 17, 2012·Journal of Endourology·Mathew D SorensenMichael R Bailey

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Citations

Nov 7, 2016·Pediatric Radiology·Gabrielle C ColleranJeanne S Chow
Nov 14, 2017·Physics in Medicine and Biology·Julianna C SimonMichael R Bailey
Aug 30, 2017·Journal of Endourology·Bryan W CunitzMatthew Bruce
Mar 5, 2019·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Abdullah E LaherAhmed Adam
Dec 11, 2020·Ultrasound Quarterly·Neena David, Mindy M Horrow
Feb 20, 2021·Ultrasound in Medicine & Biology·Eric RokniJulianna C Simon
Apr 20, 2021·Journal of Pediatric Urology·Kathleen PuttmannAlexandra W Rehfuss

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