Clinical effectiveness of seven-valent pneumococcal conjugate vaccine (Prevenar) against invasive pneumococcal diseases: prospects for children in France

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
S BlackP Reinert

Abstract

A seven-valent pneumococcal polysaccharide-CRM197 carrier protein conjugate vaccine (PNC7V; Prevenar, Wyeth, Paris) targets the serotypes (belonging to serogroups 14, 6, 19, 18, 23, 9, and 4) most often responsible for invasive pneumococcal disease (IPD) among children. A randomized, controlled, double-masked study among 37,868 children in northern California (Northern California Kaiser Permanente, USA) provided a per protocol vaccine efficacy value of 97.7% against invasive pediatric IPD due to the vaccine serotypes. The PNC7V vaccine was registered by the European Agency for the Evaluation of Medicinal Products (EMEA) in October 2000; a favorable "Community Marketing Decision" under the Centralized Procedure was granted in February 2001. PNC7V was recommended for most infants by the Conseil Supérieur d'Hygiène Publique de France in March 2002, on the advice of the Comité Technique des Vaccinations, as S. pneumoniae in children less than 2 years of age is the primary cause of bacterial meningitis and of mortality associated with community-acquired bacterial infections. The theoretical coverage of the vaccine towards pneumococcal invasive disease in France is about 80%, which represents one of the best serotype coverage estimat...Continue Reading

References

Feb 19, 1999·International Journal of Epidemiology·I VenetzK Mühlemann
Sep 24, 1999·The Pediatric Infectious Disease Journal·H R ShinefieldJ Hansen
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Dec 20, 2000·The Journal of Infectious Diseases·K SleemanUNKNOWN Oxford Pneumococcal Surveillance Group
Feb 15, 2001·The New England Journal of Medicine·J EskolaUNKNOWN Finnish Otitis Media Study Group
May 15, 2002·The Pediatric Infectious Disease Journal·Henry ShinefieldEdwin Lewis
Dec 21, 2002·European Journal of Pediatrics·Mark A FletcherBernard Fritzell
May 2, 2003·The New England Journal of Medicine·Cynthia G WhitneyUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
Jul 3, 2003·Pediatrics·Sharon NachmanUNKNOWN Pediatric AIDS Clinical Trials Group Study 292 Team

❮ Previous
Next ❯

Citations

Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wei KongRoy Curtiss
Jul 8, 2005·Journal of Clinical Microbiology·Damien M O'halloran, Mary T Cafferkey
Jul 17, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A DesrumauxI Pin
Apr 28, 2009·Médecine et maladies infectieuses·E Varon
Dec 21, 2019·Microbiology Spectrum·D E BrilesM J Crain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
W P HausdorffG Siber
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
I ParaskakisNational Surveillance Network for Pneumococcal Resistance
The Pediatric Infectious Disease Journal
Sheldon KaplanWilliam J Barson
© 2022 Meta ULC. All rights reserved