PMID: 8939189Nov 1, 1996Paper

Clinical effects of nedocromil sodium on challenges invoking neuronal mechanisms and on virally induced symptoms

The Journal of Allergy and Clinical Immunology
P König

Abstract

Although sensory nerve activity may be important to the human airway in numerous possible ways, the relevance of "neurogenic inflammation" to the onset and development of asthma is unknown. However, several of the symptoms of asthma (bronchoconstriction, cough, and dyspnea) have a neuronal component that can be modeled in the laboratory by various stimuli that are thought to invoke sensory nerve activation. Nedocromil sodium is highly effective against bronchoconstriction induced by bradykinin, the tachykinins substance P and neurokinin A, and sulfur dioxide and metabisulfite. The results for induced cough in healthy subjects are equivocal, although the drug is effective on spontaneously occurring cough in patients with asthma. Nedocromil sodium had a modest but significant effect on symptoms associated with episodes of viral infection.

Citations

Jul 28, 1999·Allergy·T Haahtela
Jul 25, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J O Warner
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·F LavoriniM Pistolesi
Feb 23, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yaping ZhangCang-Bao Xu
Jul 16, 1999·Pediatric Pulmonology·A B Chang
Apr 24, 2004·The Cochrane Database of Systematic Reviews·A ChangP Morris
Mar 29, 2001·Der Internist·A GillissenS Zielen
Mar 29, 2000·The Medical Journal of Australia·A B Chang, C F Robertson

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