Clinical Effects of Piribedil in Adjuvant Treatment of Parkinson's Disease: A Meta-Analysis

Open Medicine
Lu Peihua, Wang Jianqin

Abstract

To evaluate the clinical effects of piribedil in adjuvant treatment of Parkinson's Disease (PD) by pooling previously openly published studies. The related electronic databases of Medline (1960~2017.5), Cochrane central register of controlled trials (CENTRAL), EMBASE (1980~2017.5) and Wanfang (1986~20175.5) were searched by two reviewers (Lu Peihua and Wang Jianqian) independently for publications including the topic of prospective randomized controlled trials about clinical effects of piribedil in adjuvant treatment of PD. The data of each included study was extracted and pooled by Stata11.0 software (for meta-analysis). The statistical heterogeneity across the studies was evaluated by I2 test and the publication bias was calculated by begg's funnel plot and Egger's line regression test. After searching the related electronic databases of Medline, CENTRAL, EMBSE and Wanfang databases, 11 clinical studies were included in this meta-analysis. The pooled RR (random effect model) of clinical efficacy was 1.29 (95%CI:1.18~1.41, P=4×10-3) indicating the clinical efficacy of piribedil group was signficat higher than those of control group. The standard mean difference (SMD) for UPDRS score changed before and after treatment was poole...Continue Reading

References

Jun 17, 1999·Journal of Neural Transmission. Supplementum·E C Hirsch
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Marc ZieglerOlivier Rascol
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 21, 2007·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·José A LoeraRichard R Rahr
Oct 14, 2009·International Journal of Surgery·Nawal BahalDaniel K Sokol
Apr 2, 2013·Brain : a Journal of Neurology·Stéphane ThoboisPaul Krack
May 23, 2014·Current Topics in Behavioral Neurosciences·Susanne A Schneider, Jose A Obeso
Jul 15, 2015·PloS One·Erika F AugustineOksana Suchowersky
Feb 6, 2016·Expert Review of Neurotherapeutics·Santiago Perez-Lloret, Olivier Rascol
Jun 28, 2016·CNS Drugs·Santiago Perez-Lloret, Olivier Rascol
Sep 5, 2017·Bioorganic & Medicinal Chemistry Letters·J Michael Ellis, Matthew J Fell

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