Clinical effects of reverting from leukoreduced to nonleukoreduced blood in cardiac surgery

Transfusion
Mark K FungDarrell J Triulzi

Abstract

A reduction in postoperative length of stay (PLOS) was recently demonstrated with the use of leukoreduced (LR) blood in cardiac surgery patients compared to a historical cohort who received non-LR blood. Follow-up data are now presented in a similar population after a 12-month period in which LR blood was no longer routinely used. This is an extension of a study in which all patients admitted over a 12-month period for open heart surgery were given LR blood (Group 2) and were compared against a historical cohort given non-LR blood (Group 1). This study measures the outcomes of a new cohort of patients admitted during a 12-month period where LR blood was no longer routinely used (Group 3). PLOS increased in patients who received transfusions with non-LR blood (Group 3, n = 595) versus patients with LR blood (Group 2, n = 645; p = 0.045 by nonparametric rank U test). Mean PLOS increased from 9.5 days (95% confidence interval [CI], 8.9-10.0) to 10.8 days (95% CI, 10.0-11.6). In comparison, an earlier cohort who received non-LR blood (Group 1, n = 501) had a mean PLOS of 10.1 days (95% CI, 9.4-10.7). With the exception of decreased red blood cell (RBC) usage in Group 3, there were no significant differences in non-RBC blood usage, ...Continue Reading

References

Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
May 15, 2002·Perfusion·George Asimakopoulos
Sep 11, 2002·American Journal of Clinical Pathology·Neil BlumbergScott A Kirkley
Nov 15, 2002·Transfusion·W H DzikC P Stowell
Apr 17, 2003·JAMA : the Journal of the American Medical Association·Paul C HébertUNKNOWN Leukoreduction Study Investigators
May 7, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dean FergussonPaul C Hébert

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Citations

Feb 14, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Banu AyhanUlku Aypar
Sep 18, 2012·Blood Cells, Molecules & Diseases·Katie L LannanNeil Blumberg
Jul 27, 2007·Best Practice & Research. Clinical Anaesthesiology·Emre Almac, Can Ince
Dec 17, 2008·Vox Sanguinis·T TasakiY Hoshi
Apr 27, 2010·The Journal of Thoracic and Cardiovascular Surgery·Gianpaolo RomanoLuca Salvatore De Santo
Mar 19, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lisa J CardoDonna Wilder
Mar 25, 2015·Biological Chemistry·Richard S HoehnTimothy A Pritts

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