Clinical effects of switching from minodronate to denosumab treatment in patients with postmenopausal osteoporosis: a retrospective study

BMC Women's Health
Masaki KobayashiTadashi Kimura

Abstract

Denosumab is a major treatment option for patients with postmenopausal osteoporosis; however, the evidence for its use is lacking. Therefore, in this 24-month retrospective study, we aimed to evaluate the effects of switching from minodronate (MIN) to denosumab in these patients. Patients with postmenopausal osteoporosis either switched from MIN to denosumab (Group 1; n = 32) or continued MIN treatment (Group 2; n = 24). Bone mineral density (BMD) of the lumbar spine (L2-L4) and femoral neck was assessed at baseline and every 6 months for 24 months. Serum bone-specific alkaline phosphatase (BAP) and N-terminal telopeptide were measured at baseline, 12 months, and 24 months. Twenty-nine of the 32 patients (90.6%) in group 1 and all patients (24/24) in group 2 completed the 24-month follow-up. Switching from MIN to denosumab (Group 1) significantly increased lumbar BMD at 12, 18, and 24 months (6.1, 7.4, and 9.6%, respectively) and femoral neck BMD at 12, 18, and 24 months (2.8, 3.2, and 3.4%, respectively), whereas MIN continuous treatment (Group 2) showed no significant difference from baseline. Switching therapy also showed a significant decrease in serum BAP from baseline to 12 and 24 months (- 19.3 and - 26.5%, respectively)...Continue Reading

References

Nov 13, 1993·BMJ : British Medical Journal·G S KeeneG A Pryor
Dec 1, 1996·Australian and New Zealand Journal of Public Health·R G CummingA Katelaris
Dec 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T MatsumotoT Nakamura
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David L KendlerHenry G Bone
Aug 13, 2009·The New England Journal of Medicine·Steven R CummingsUNKNOWN FREEDOM Trial
Dec 15, 2010·Bone·Roland BaronR Graham G Russell
Sep 13, 2012·International Journal of Clinical Practice·D A HanleyV Brown
Oct 4, 2012·The Journal of Bone and Joint Surgery. American Volume·Graeme HoltDamien Reid
Feb 27, 2013·Clinical Interventions in Aging·Shinji Tanishima, Yasuo Morio
Apr 5, 2013·Journal of Bone and Mineral Metabolism·Satoshi SoenUNKNOWN Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the Revision of the
Apr 22, 2014·Patient Preference and Adherence·Tsuyoshi MiyazakiSakae Tanaka
Jul 6, 2014·The Medical Clinics of North America·Matthew A Varacallo, Ed J Fox
May 13, 2015·Nature Reviews. Endocrinology·Ian R Reid
Aug 19, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L KarlssonO Ström
Jun 9, 2016·The Journal of Clinical Endocrinology and Metabolism·P D MillerS R Cummings
Oct 26, 2016·Menopause : the Journal of the North American Menopause Society·Rebecca L DrielingSusan R Heckbert
Mar 16, 2017·European Journal of Rheumatology·Tümay SözenNursel Çalık Başaran
May 31, 2017·Journal of the American Geriatrics Society·Rebecca L DrielingSusan R Heckbert
Nov 23, 2017·Frontiers in Pharmacology·Vito PavoneGiuseppe Sessa
May 2, 2018·Therapeutics and Clinical Risk Management·Tsuyoshi Ohishi, Yukihiro Matsuyama
Nov 6, 2018·Cleveland Clinic Journal of Medicine·Stuart SilvermanSusan Bukata
Dec 12, 2018·The Journal of Clinical Endocrinology and Metabolism·Houchen LyuDaniel H Solomon
Dec 26, 2018·Maturitas·Panagiotis AnagnostisDimitrios G Goulis
May 22, 2019·Journal of Oral Biosciences·Shinichiro KuroshimaTakashi Sawase
Nov 30, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P D MillerJ P Brown

❮ Previous
Next ❯

Citations

Jul 27, 2021·Expert Review of Endocrinology & Metabolism·Hotaka IshizuNorimasa Iwasaki
Aug 28, 2021·Experimental and Therapeutic Medicine·Xiaoya GaoKechun Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
hormone replacement therapy
enzyme-linked immunosorbent assay

Software Mentioned

JMP Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.