Clinical efficacy and feasibility of whey protein isolates supplementation in malnourished peritoneal dialysis patients: A multicenter, parallel, open-label randomized controlled trial

Clinical Nutrition ESPEN
Sharmela SahathevanTilakavati Karupaiah

Abstract

Poor dietary intake is commonly associated with malnutrition in the dialysis population and oral nutritional supplementation is strategized to redress dietary inadequacy. Knowledge on clinical efficacy of whey protein supplementation (WPS) as an option to treat malnutrition in continuous ambulatory peritoneal dialysis (CAPD) patients is limited. This multicenter, parallel, open-label, randomized controlled trial investigated the clinical efficacy of WPS in 126 malnourished CAPD patients with serum albumin <40 g/L and body mass index (BMI) <24 kg/m2. Patients randomized to the intervention group (IG, n = 65) received protein powder (27.4 g) for 6 months plus dietary counseling (DC) while the control group (CG, n = 61) received DC only. Anthropometry, biochemistry, malnutrition-inflammation-score (MIS), dietary intake inclusive of dialysate calories, handgrip strength (HGS) and quality of life (QOL) were assessed at baseline and 6 months. Clinical outcomes were assessed by effect size (Cohen's d) comparisons within and between groups. Seventy-four patients (n = 37 per group) completed the study. Significantly more IG patients (59.5%) achieved dietary protein intake (DPI) adequacy of 1.2 g/kg per ideal body weight (p < 0.001) comp...Continue Reading

Associated Clinical Trials

Dec 8, 2017·Tilakavati Karupaiah

Citations

May 12, 2020·The Cochrane Database of Systematic Reviews·Jia Yee MahLawrence P McMahon
Oct 4, 2020·Current Opinion in Nephrology and Hypertension·Daniela Viramontes-Hörner, Maarten W Taal
Dec 22, 2021·The Cochrane Database of Systematic Reviews·Christine BaldwinChristine Elizabeth Weekes

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