Abstract
Although itraconazole exhibits potent activity against Candida species, there have been few studies examining the use of intravenous itraconazole in the treatment of invasive candidiasis. A nationwide multicenter clinical study was conducted to evaluate the efficacy and safety of intravenous itraconazole in the management of invasive candidiasis, including non-albicans Candida species, in non-neutropenic patients undergoing surgery and critical care. Between September 2007 and August 2009, patients with proven and presumed candidiasis were enrolled at 22 participating institutions. Patients with presumed candidiasis had a deep-body temperature of 37.8°C or higher and were positive for serum β-D: -glucan or two or more colonization sites of Candida species. The main exclusion criterion was severe renal impairment (creatinine clearance <30 ml/min). The primary efficacy analysis was based on clinical and microbiological responses 5-10 days after the end of treatment, assessed by an independent data review committee. Of the 60 patients enrolled, 49 were included in the modified intention-to-treat population; 31 patients received a definitive diagnosis and 18 patients a presumed diagnosis. Intravenous itraconazole was used as first-...Continue Reading
References
Nov 17, 1994·The New England Journal of Medicine·J H RexA P Dine
Mar 18, 2000·Journal of Chemotherapy·T F Patterson
Aug 7, 2001·Mycoses·D P KontoyiannisC S Mantzoros
Mar 7, 2002·Journal of Clinical Microbiology·M A PfallerUNKNOWN SENTRY Participants Group
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W E TrickUNKNOWN National Nosocomial Infections Surveillance System Hospitals
Oct 10, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Naoki AikawaYoji Yamazaki
Dec 20, 2002·The New England Journal of Medicine·Jorge Mora-DuarteUNKNOWN Caspofungin Invasive Candidiasis Study Group
May 13, 2003·Chest·Jordi VallésMiguel Angel Alcalá
Nov 20, 2004·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Minoru Yoshida
Oct 26, 2005·Lancet·B J KullbergM R Hodges
Apr 21, 2006·Critical Care Medicine·Anand KumarMary Cheang
Jun 20, 2007·The Journal of Antimicrobial Chemotherapy·Michael D ParkinsKevin B Laupland
Dec 18, 2007·The Journal of Infection·Graeme N ForrestJennifer K Johnson
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Jul 23, 2009·The Journal of Antimicrobial Chemotherapy·Matteo BassettiClaudio Viscoli
Aug 19, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Naoki AikawaHideharu Tanaka
Sep 17, 2010·Pathologie-biologie·S BertoutM Mallié
Citations
Feb 7, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupUNKNOWN Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility T
Jun 12, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Dionyssia-Pinelopi CarrerEvangelos J Giamarellos-Bourboulis