Clinical Efficacy and Safety of Xinmailong Injection for the Treatment of Chronic Heart Failure: A Meta-Analysis

Frontiers in Pharmacology
Xiaohua LuXiaohe Xiao

Abstract

Background: Chronic heart failure (CHF) is one of the most stubborn cardiovascular disease. Xinmailong (XML), a bioactive fraction extracted from Periplaneta americana L., has been commonly used for CHF treatment in China. However, there is few comprehensive evaluation for the clinical efficacy and safety of XML for CHF. Objectives: We aimed to evaluate the beneficial and adverse effects of Xinmailong Injection (XMLI) on CHF treatment with the use of meta-analysis. Methods: In accordance with the Cochrane Handbook and transparent reporting of systematic reviews and meta-analysis protocol (CRD42018087091), seven English and Chinese electronic databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, VIP medicine information system and China Biomedical Literature Database (CBM), were searched to retrieve potential randomized controlled trials (RCTs) before November 2017. The eligible trials were evaluated for methodological quality. The main outcome measures were analyzed with RevMan 5.3 software. Results: 26 RCTs involving 3447 participants were subjected to meta-analysis. The total effective rate was improved by XMLI plus conventional therapy (OR 3.10, 95% CI 2.47...Continue Reading

References

Apr 24, 2007·Journal of the American College of Cardiology·Patrick JourdainYves Juillière
Mar 18, 2010·British Journal of Clinical Pharmacology·Stefan Vegter, Lolkje T W de Jong-van den Berg
Apr 10, 2013·International Journal of Medical Sciences·Qilin MaFengfeng Zhou
Feb 5, 2014·Journal of the American College of Cardiology·Andrew P AmbrosyMihai Gheorghiade
Jul 6, 2014·Heart Failure Reviews·Mark OremusParminder Raina
Nov 30, 2014·The American Journal of Medicine·Anu Agarwal, Ezra A Amsterdam
Apr 17, 2015·The Medical Journal of Australia·Karen Page
Nov 25, 2016·Drug Design, Development and Therapy·Xiaoyi WangWentao Zhu

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Software Mentioned

XMLI
RevMan

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