PMID: 8971673Dec 1, 1996Paper

Clinical efficacy of ampicillin, pivampicillin and procaine penicillin G in a soft tissue infection model in ponies

Journal of Veterinary Pharmacology and Therapeutics
J M EnsinkA S van Miert

Abstract

Tissue chambers, implanted subcutaneously in ponies, were inoculated with Streptococcus zooepidemicus. The animals received either no antibiotics or one of the following treatments: pivampicillin per os (19.9 mg/kg, equivalent to 15 mg/kg ampicillin, every 12 h) for 7 or 21 days (7 and 5 ponies, respectively), procaine penicillin G intramuscularly (12 mg/kg = 12,000 IU/kg, every 24 h) for 7 days (7 ponies), or ampicillin sodium intravenously (equivalent to 15 mg/ kg ampicillin, every 8 h) for 1 day (5 ponies). Only intravenous administration was started before infection (prophylactically), the other treatments were started 20 h after infection (curatively). A total of 7 ponies received no antibiotics. In untreated controls, the infection led to abscessation of the tissue chamber in 4 to 10 days. Curative treatment with either pivampicillin or procaine penicillin G for 7 days resulted in a reduction of viable bacteria in the tissue chamber but did not eliminate the infection, resulting in abscessation in 5 to 14 days. However, administration of pivampicillin for 21 days eliminated the streptococci in five out of five ponies and prophylactic administration of ampicillin was successful in three out of five ponies.

References

Sep 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·J M EnsinkA G Vulto
Mar 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·R E BeadleC R Clarke
Aug 6, 1983·The Veterinary Record·J B Woolcock, M D Mutimer
Sep 1, 1984·Journal of Veterinary Pharmacology and Therapeutics·K J VarmaS L Spurlock
Dec 1, 1994·The Analyst·J Fink-Gremmels, A S van Miert

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Citations

Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·M VoermansJ M Ensink
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·G BoschJ M Ensink
Dec 18, 2002·Journal of Veterinary Pharmacology and Therapeutics·C GrekoJ Luthman
Apr 1, 2012·Equine Veterinary Education·M MallicoteL C Sanchez
Jun 1, 2021·Journal of Veterinary Pharmacology and Therapeutics·Ronan J J ChapuisPatricia M Dowling
Jun 3, 2021·Animal Health Research Reviews·Luís DionísioAna I Faustino-Rocha

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