Clinical efficacy of etanercept versus sulfasalazine in ankylosing spondylitis subjects with peripheral joint involvement

The Journal of Rheumatology
Jurgen BraunAndrew S Koenig

Abstract

Etanercept, a fully human tumor necrosis factor soluble receptor, is effective in treatment of ankylosing spondylitis (AS). Current guidelines suggest sulfasalazine (SSZ) treatment as initial therapy for the management of patients with AS with peripheral arthritis versus therapy with biologics. We compared the efficacy of etanercept with SSZ in patients with AS with peripheral joint involvement. The efficacy of etanercept 50 mg once weekly was compared with that of SSZ up to 3 g daily in subjects with ≥ 1 swollen peripheral joint at baseline, using data from a 16-week randomized double-blind study in subjects with AS. Efficacy was assessed by the Assessment in AS criteria and the Bath AS Disease Activity, Functional, and Metrology indices. The last observation carried forward method was used for imputation of missing values. Of 566 subjects included in original study, 181 (etanercept 121; SSZ 60) had ≥ 1 swollen peripheral joint and 364 (etanercept 250; SSZ 124) had none at baseline. AS patients treated with etanercept showed significantly greater improvement than those treated with SSZ in all joint assessments regardless of swollen joint involvement. In this analysis, etanercept was significantly more effective than SSZ for ma...Continue Reading

References

Nov 13, 2003·Arthritis and Rheumatism·John C DavisUNKNOWN Enbrel Ankylosing Spondylitis Study Group
Sep 4, 2004·Annals of the Rheumatic Diseases·A CalinS Fatenejad
Aug 30, 2005·Annals of the Rheumatic Diseases·J ZochlingUNKNOWN European League Against Rheumatism
Apr 24, 2007·Lancet·Jürgen Braun, Joachim Sieper
May 5, 2009·The Journal of Rheumatology·Ben DijkmansJoseph Wajdula
Sep 8, 2009·Advances in Experimental Medicine and Biology·Jürgen Braun

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Citations

Mar 25, 2014·Expert Opinion on Investigational Drugs·Juergen BraunUta Kiltz
Jan 13, 2015·Expert Opinion on Emerging Drugs·Juergen BraunXenofon Baraliakos
Jan 15, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingUNKNOWN French Society for Rheumatology (SFR)
Jun 16, 2015·Expert Opinion on Pharmacotherapy·Carlo PalazziIgnazio Olivieri
Oct 4, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jinzhu ZhaoWeidong Xu
May 21, 2013·Rheumatology International·Marina Amaral de Ávila MachadoFrancisco de Assis Acurcio
Nov 28, 2014·The Cochrane Database of Systematic Reviews·Junmin ChenChao Liu
Apr 19, 2015·The Cochrane Database of Systematic Reviews·Lara J MaxwellGeorge A Wells
Jul 7, 2017·Expert Opinion on Biological Therapy·Xavier GuillotDaniel Wendling
Mar 17, 2017·The Medical Journal of Australia·Matt Brown, Linda A Bradbury

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