Abstract
It has recently been suggested that the use of fine-needle aspiration (FNA) biopsy of thyroid nodules in male patients is associated with an unacceptably high false-negative rate in the detection of thyroid malignancy. We hypothesize that FNA biopsy is an accurate preoperative tool for detecting thyroid cancer in men, and that false negative rates are significantly lower than recently reported. A retrospective database analysis was performed on all male patients who underwent thyroid surgery from May 1994 through January 2007 at a single institution. The results of preoperative FNA biopsies were compared with final surgical pathologic results. FNA biopsy results were reported as benign, malignant, inconclusive (i.e., follicular neoplasm), or nondiagnostic; final surgical pathology was reported as benign or malignant. Of 1205 patients who underwent thyroidectomy, 273 (23%) were male. Preoperative FNA biopsy results were obtained in 60% of these male patients and were read as benign in 45/165 (27%) patients, malignant in 47/165 (28%) patients, inconclusive in 66/165 (40%) patients, and nondiagnostic in 7/165 (4%) patients. In male patients with cytology reported as benign, 3/45 (6.7%) FNAs were determined to be malignant on final...Continue Reading
References
Sep 1, 1968·Annals of Internal Medicine·J B VanderT R Dawber
Nov 1, 1994·The American Journal of Medicine·E L Mazzaferri, S M Jhiang
Aug 22, 1994·Archives of Internal Medicine·S EzzatG D Braunstein
Feb 15, 1993·Annals of Internal Medicine·H Gharib, J R Goellner
Feb 25, 1993·The New England Journal of Medicine·E L Mazzaferri
May 1, 1998·Annals of Surgery·H ChenR Udelsman
May 20, 1998·Thyroid : Official Journal of the American Thyroid Association·C CarmeciR J Weigel
Jun 12, 1998·Thyroid : Official Journal of the American Thyroid Association·R M TuttleH B Burch
Nov 11, 1998·Journal of the American College of Surgeons·L A BoydJ B Hanks
Jun 1, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J F CarrilloM Ibarra
Mar 22, 2001·Archives of Pathology & Laboratory Medicine·M AmrikachiT M Wheeler
May 5, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D L MandellM L Urken
Feb 22, 2002·AJR. American Journal of Roentgenology·Eun-Kyung KimHyung Sik Yoo
Oct 1, 1955·The Journal of Clinical Endocrinology and Metabolism·J D MORTENSENW A BENNETT
Oct 22, 2004·The New England Journal of Medicine·Laszlo Hegedüs
Feb 21, 2006·Thyroid : Official Journal of the American Thyroid Association·Rachel RedmanNicole A Massoll
Apr 15, 2006·Annals of Surgical Oncology·David Y GreenblattHerbert Chen
Jul 13, 2006·The Journal of Clinical Endocrinology and Metabolism·Mary C FratesErik K Alexander
Jul 15, 2006·Thyroid : Official Journal of the American Thyroid Association·Mustafa CesurNuri Kamel
Dec 14, 2006·Advances in Surgery·Jennifer B OgilvieOrlo H Clark
Dec 8, 2007·Surgery·Kelly L McCoyJohn H Yim
Jan 22, 2008·American Journal of Surgery·Richard N Berri, Larry R Lloyd
Jan 29, 2008·World Journal of Surgery·Rebecca S SippelOrlo H Clark
Jul 31, 2008·Annals of Surgical Oncology·Yi Wei ZhangHerbert Chen
Dec 2, 2008·Surgery·Christopher R McHenryRhoderick N Machekano
Dec 17, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S A PolyzosA Avramidis
Jul 22, 2009·Archives of Surgery·Scott N PinchotHerbert Chen
Citations
Apr 3, 2013·Archives of Pathology & Laboratory Medicine·Robert L SchmidtLester J Layfield
May 3, 2011·The Journal of Surgical Research·Nicholas CooroughHerbert Chen
Mar 2, 2010·The Journal of Surgical Research·Barbra S Miller
Jun 24, 2017·Endocrine Pathology·Anna Cipolletta CampanileFranco Fulciniti
Oct 5, 2011·Acta Radiologica·Jin ChungEun Ju Son
Apr 12, 2019·Journal of Ultrasound·Mehrdad NabahatiMajid Sharbatdaran