Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study

Pediatric Dermatology
Naoki HashizumeYoshiaki Tanaka

Abstract

Lymphatic malformations (LMs) are congenital malformations of the lymphatic system that commonly affect the head and neck region and cause marked cosmetic and functional complications. In this pilot study, we present eight children with LMs treated using an herbal medicine for this indication. Between January 2009 and May 2014, eight children (four boys, four girls) with LMs were treated using oral administration of an herbal medicine, Eppikajyutsuto (TJ-28; Tsumura, Tokyo, Japan), as monotherapy. Four of the cases were macrocystic and four were mixed micro- and macrocystic. The mean treatment duration was 7.2 ± 2.9 months (range 5-12 mos). The mean LM volume shrinkage on magnetic resonance imaging was 54.5 ± 38.3% (macrocystic 73.6 ± 27.0%; mixed micro- and macrocystic 35.4 ± 41.5%). One of four macrocystic lesions had a marked reduction, two had a moderate reduction, and one had no response. A marked reduction was observed in three of the four mixed micro- and macrocystic cases; the other mixed cystic case had no response. The treatment was well tolerated, without severe adverse events. This preliminary study demonstrates the beneficial effects of TJ-28. Further evaluations of this therapeutic modality are warranted.

References

Aug 1, 1987·The British Journal of Surgery·S OgitaT Takahashi
Feb 14, 2002·Pediatric Dermatology·C H LaiS B Mallory
Dec 4, 2003·Jornal de pediatria·R J Souza, L G Tone
Nov 23, 2005·Archives of Otolaryngology--head & Neck Surgery·Douglas M SidleSusan E Crawford
Feb 3, 2007·Journal of Pediatric Surgery·Tadaharu OkazakiAtsuyuki Yamataka
Aug 1, 1985·Planta medica·Y KasaharaK Ohuchi
May 17, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Keiko Ogawa-OchiaiKatsutoshi Terasawa
Jul 10, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·B O'SullivanUNKNOWN Members of the IMRT Indications Expert Panel
Mar 25, 2014·Journal of the American Academy of Dermatology·Christina DanialAlfred T Lane
Jun 5, 2015·European Journal of Pediatrics·Herwig LacknerChristian E Urban

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Citations

Aug 9, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryo SueyoshiTakashi Doi
Sep 15, 2018·Clinical Case Reports·Hideaki TanakaHajime Kawakami
Jun 12, 2019·Case Reports in Pediatrics·Takayuki FujiiHiroto Katami
Oct 6, 2020·Journal of Pediatric Surgery·Shotaro MatsuderaTakuya Yazawa
Oct 5, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Juma ObayashiHiroaki Kitagawa

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

JMP

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