Abstract
Lymphatic malformations (LMs) are congenital malformations of the lymphatic system that commonly affect the head and neck region and cause marked cosmetic and functional complications. In this pilot study, we present eight children with LMs treated using an herbal medicine for this indication. Between January 2009 and May 2014, eight children (four boys, four girls) with LMs were treated using oral administration of an herbal medicine, Eppikajyutsuto (TJ-28; Tsumura, Tokyo, Japan), as monotherapy. Four of the cases were macrocystic and four were mixed micro- and macrocystic. The mean treatment duration was 7.2 ± 2.9 months (range 5-12 mos). The mean LM volume shrinkage on magnetic resonance imaging was 54.5 ± 38.3% (macrocystic 73.6 ± 27.0%; mixed micro- and macrocystic 35.4 ± 41.5%). One of four macrocystic lesions had a marked reduction, two had a moderate reduction, and one had no response. A marked reduction was observed in three of the four mixed micro- and macrocystic cases; the other mixed cystic case had no response. The treatment was well tolerated, without severe adverse events. This preliminary study demonstrates the beneficial effects of TJ-28. Further evaluations of this therapeutic modality are warranted.
References
Aug 1, 1987·The British Journal of Surgery·S OgitaT Takahashi
Apr 1, 1985·Planta medica·C KonnoH Hikino
Dec 16, 2000·The New England Journal of Medicine·C A Haller, N L Benowitz
Feb 14, 2002·Pediatric Dermatology·C H LaiS B Mallory
Dec 4, 2003·Jornal de pediatria·R J Souza, L G Tone
Jul 12, 2005·Journal of Pharmacological Sciences·Kohichi AokiYasushi Ohizumi
Nov 23, 2005·Archives of Otolaryngology--head & Neck Surgery·Douglas M SidleSusan E Crawford
Jan 13, 2006·Journal of Pharmacological Sciences·Mi-Jung YeomDae-Hyun Hahm
Feb 3, 2007·Journal of Pediatric Surgery·Tadaharu OkazakiAtsuyuki Yamataka
Aug 1, 1985·Planta medica·Y KasaharaK Ohuchi
May 17, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Keiko Ogawa-OchiaiKatsutoshi Terasawa
Jul 10, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·B O'SullivanUNKNOWN Members of the IMRT Indications Expert Panel
Mar 25, 2014·Journal of the American Academy of Dermatology·Christina DanialAlfred T Lane
Feb 15, 2015·The Journal of Pediatrics·Valerie L LuksRudy Murillo
Jun 5, 2015·European Journal of Pediatrics·Herwig LacknerChristian E Urban
Citations
Mar 24, 2016·Pediatric Dermatology·Peter A Lio
Aug 9, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryo SueyoshiTakashi Doi
Sep 15, 2018·Clinical Case Reports·Hideaki TanakaHajime Kawakami
Jun 12, 2019·Case Reports in Pediatrics·Takayuki FujiiHiroto Katami
Jul 19, 2017·Surgical Case Reports·Toko ShinkaiNao Tanaka
Oct 6, 2020·Journal of Pediatric Surgery·Shotaro MatsuderaTakuya Yazawa
Oct 6, 2021·BMJ Case Reports·Elena Yukie UebayashiNarito Takada
Oct 5, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Juma ObayashiHiroaki Kitagawa
Dec 24, 2021·Medicine·Keiko Ogawa-OchiaiHiroomi Okuyama