Clinical efficacy of horsechestnut seed extract in the treatment of venous ulceration

Journal of Wound Care
Matthew J LeachG Foster

Abstract

To evaluate the clinical efficacy of orally administered horsechestnut seed extract in the treatment of venous leg ulcers. In a prospective triple-blind randomised placebo-controlled trial, 54 patients with venous leg ulcers from a large South Australian community nursing service were randomly allocated to receive horsechestnut seed extract (n=27) or placebo (n=27) for 12 weeks. Ulcers were assessed at weeks 0, 4, 8 and 12 utilising a wound assessment tool and the Alfred/Medseed Wound Imaging System. The difference between groups in the number of healed leg ulcers and change in wound surface area, depth, volume, pain and exudate was not statistically significant. However, horsechestnut seed extract did have a significant effect on the percentage of wound slough over time (RM-ANOVA F=2.76, p=0.045) and on the number of dressing changes at week 12 (t=-2.71, p=0.009). Even though horsechestnut seed extract is likely to attenuate the pathogenesis of venous insufficiency and, in turn, facilitate venous ulcer healing, the current study did not statistically support such a claim. However, taking into account the small sample and insufficient power of the trial, and the significant improvement in wound slough and visit frequency, it ap...Continue Reading

References

May 30, 1987·British Medical Journal·M J CallamC V Ruckley
Jun 22, 1985·British Medical Journal·M J CallamJ J Dale
Apr 1, 1994·The Australian and New Zealand Journal of Surgery·S R Baker, M C Stacey
Oct 1, 1996·Journal of Wound Care·E A Nelson
May 1, 1997·Journal of Wound Care·D HofmanC Glynn
Aug 1, 1997·Controlled Clinical Trials·L C LovatoJ L Probstfield
Sep 26, 1997·BMJ : British Medical Journal·A FletcherT A Sheldon
Apr 8, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S E Zimmet
Dec 2, 1999·Journal of Clinical Epidemiology·S RossR Prescott
Apr 26, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·V FalangaW Wolf
Dec 29, 2000·Aging : Clinical and Experimental Research·I BerghB Steen
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R Sirtori
Dec 6, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·P E BijurE J Gallagher
Feb 23, 2002·Collegian : Journal of the Royal College of Nursing, Australia·N Santamaria, L Clayton
Mar 21, 2002·Journal of Wound Care·R Baxter, H Baxter
Jul 5, 2002·The American Journal of Emergency Medicine·E John GallagherWendy Silver

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Citations

Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Ronda S Farah, Mark D P Davis
Nov 17, 2009·Microvascular Research·Xia LiShen-Jiang Hu
Jun 19, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Joseph D RaffettoFerdinando Mannello
Apr 30, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C WittensUNKNOWN European Society for Vascular Surgery
May 11, 2017·International Wound Journal·Anderson L FreitasFrancilene A da Silva
Sep 15, 2015·The Cochrane Database of Systematic Reviews·Georgina GethinDinanda N Kolbach
Dec 16, 2016·Journal of Wound Care·M BuzziM de Barros Winter
Jun 20, 2018·The Indian Journal of Surgery·Ravul JindalRoy Varghese

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