Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature

European Urology
Giorgio Ivan RussoMaarten Albersen

Abstract

Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain. To summarise the available evidence regarding injection and mechanical therapies for PD treatment. An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up to 15 May 2018. The systematic review protocol was registered on PROSPERO (CRD42017077050). Inclusion criteria were as follows: adults with early or chronic PD receiving treatment with injection therapy, penile traction, or a vacuum device. Fifty-two articles were selected according to the inclusion criteria-17 comparative studies and 35 cohort studies-analysing the effects of calcium channel blockers (verapamil, nicardipine), collagenase Clostridium histolyticum (CCH), interferon α-2b (IFNα-2b), hyaluronic acid (HA), onabotulinum toxin A, thiocolchicine, penile extender devices, and vacuum devices. Qualitative data from these studies suggest a clinically significant effect of CCH and IFNα-2b injection therapy to decrease penile curvature and conserve penile length. Verapamil and HA performed well in single-arm or case-control studies. Studies of pe...Continue Reading

Citations

Dec 7, 2018·Expert Opinion on Emerging Drugs·U MilenkovicM Albersen
Oct 28, 2018·Nature Reviews. Urology·Uros MilenkovicFabio Castiglione
Sep 22, 2019·Medical Sciences : Open Access Journal·Patrick Teloken, Darren Katz
Oct 9, 2019·International Journal of Impotence Research·Giorgio Ivan RussoUNKNOWN EAU-YAU Men’s Health Working Group
Jun 11, 2020·F1000Research·Asrit Babu, Oliver Kayes
May 21, 2020·Frontiers in Pharmacology·Natalija PopovićMiroljub Popović
Apr 8, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Matthew J ZiegelmannLaurence A Levine
Jan 10, 2021·Current Urology Reports·Ayad YousifWayne J G Hellstrom

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