Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

Lancet
Sobha SivaprasadCLARITY Study Group

Abstract

Proliferative diabetic retinopathy is the most common cause of severe sight impairment in people with diabetes. Proliferative diabetic retinopathy has been managed by panretinal laser photocoagulation (PRP) for the past 40 years. We report the 1 year safety and efficacy of intravitreal aflibercept. In this phase 2b, single-blind, non-inferiority trial (CLARITY), adults (aged ≥18 years) with type 1 or 2 diabetes and previously untreated or post-laser treated active proliferative diabetic retinopathy were recruited from 22 UK ophthalmic centres. Patients were randomly assigned (1:1) to repeated intravitreal aflibercept (2 mg/0·05 mL at baseline, 4 weeks, and 8 weeks, and from week 12 patients were reviewed every 4 weeks and aflibercept injections were given as needed) or PRP standard care (single spot or mutlispot laser at baseline, fractionated fortnightly thereafter, and from week 12 patients were assessed every 8 weeks and treated with PRP as needed) for 52 weeks. Randomisation was by minimisation with a web-based computer generated system. Primary outcome assessors were masked optometrists. The treating ophthalmologists and participants were not masked. The primary outcome was defined as a change in best-corrected visual acui...Continue Reading

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Citations

May 13, 2017·Lancet·Daniel Shu Wei Ting, Tien Yin Wong
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Tanya MoutrayAugusto Azuara-Blanco
Apr 18, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Peter H TangDiana V Do
Jul 19, 2019·JAMA Ophthalmology·Anat LoewensteinAnnabelle A Okada
Aug 16, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Elie H MotulskyPhilip J Rosenfeld
Oct 30, 2018·Investigative Ophthalmology & Visual Science·Luke NicholsonSobha Sivaprasad
Jul 10, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Reinhard AngermannClaus Zehetner
Feb 27, 2019·Retina·Susan B BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network
Apr 23, 2020·The New England Journal of Medicine·Lee M JampolJennifer Sun
Jun 11, 2019·BMJ Open Ophthalmology·Usha ChakravarthySusanne Lupton
Apr 30, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Andrew A MoshfeghiJonathan Prenner
Oct 27, 2018·Diabetes & Metabolism Journal·Sentaro KusuharaAkiyoshi Uemura
May 19, 2020·Acta Ophthalmologica·Anna Stage Vergmann, Jakob Grauslund
Oct 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shigeo YoshidaEiko Tsuiki
Jun 22, 2018·International Journal of Molecular Sciences·Wei Wang, Amy C Y Lo
Dec 16, 2018·International Journal of Molecular Sciences·Erika GucciardoKaisa Lehti
Nov 22, 2019·Current Diabetes Reports·Michael Patrick EllisGlenn Yiu
Feb 25, 2020·Journal of Ophthalmology·Hazem AbdelmotaalKhaled Abdelazeem
May 20, 2020·The Journal of Clinical Investigation·Zoe L GrantLeigh Coultas
Apr 2, 2020·Drug Delivery and Translational Research·Biplab SarkarVivek A Kumar
Aug 2, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·YuDong FuDaBo Wang
Feb 20, 2019·Journal of Clinical Medicine·Maciej Gawęcki
Nov 23, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Felipe F ContiUNKNOWN Global Diabetic Macular Edema Study Group
Jul 26, 2018·JAMA Ophthalmology·Jeffrey G GrossUNKNOWN Diabetic Retinopathy Clinical Research Network
Sep 12, 2019·Current Diabetes Reports·Avinash HonasogeRithwick Rajagopal

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