PMID: 2478788Jan 1, 1989Paper

Clinical efficacy of pimobendan (UD-CG 115 BS) in patients with chronic congestive heart failure.

Journal of Cardiovascular Pharmacology
G BaumannB Permanetter

Abstract

The pyridazoline derivative UD-CG 115 BS (pimobendan) is a noncatecholamine, nonglycoside new inotropic compound with potent vasodilator properties that exerts stimulatory myocardial effects by increasing the Ca2+ affinity of cardiac contractile proteins, thus improving Ca2+ utilization. The aim of the present study was to characterize and quantify the hemodynamic effects of oral UD-CG 115 BS in 25 patients with idiopathic congestive cardiomyopathy (NYHA stage III) and compare these to the action of the beta 1-receptor agonist dobutamine. UD-CG 115 BS 5 mg p.o. increased cardiac output, cardiac index, and stroke volume index by approximately 60%. With only minor changes in heart rate, ventricular filling pressures decreased (-40%) and there was a decline in pulmonary and systemic vascular resistance (-50%), as well as in systolic, diastolic, and mean pulmonary artery pressure (-35%). The effects of 5 mg UD-CG 115 BS were comparable to the optimal dose of dobutamine, while 10 mg induced significantly more pronounced hemodynamic changes. The effects of UD-CG 115 BS lasted for at least 12 h. No major side effects were observed. A continuous treatment with 10 mg of UD-CG 115 BS/day over a period of 5 days resulted in a significantl...Continue Reading

Citations

Aug 25, 2004·The Veterinary Clinics of North America. Small Animal Practice·Virginia Luis Fuentes
Jun 23, 2007·Journal of Pharmacological and Toxicological Methods·Michael MarkertBrian Guth
Oct 25, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·M YataN J Beijerink

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